The Dawn of a New Pharmaceutical Epoch: Can AI and Robotics Reshape Drug Formulation?

Autor: Bannigan P; Intrepid Labs Inc., MaRS Centre, West Tower, 661 University Avenue Suite 1300, Toronto, ON, M5G 0B7, Canada., Hickman RJ; Intrepid Labs Inc., MaRS Centre, West Tower, 661 University Avenue Suite 1300, Toronto, ON, M5G 0B7, Canada., Aspuru-Guzik A; Intrepid Labs Inc., MaRS Centre, West Tower, 661 University Avenue Suite 1300, Toronto, ON, M5G 0B7, Canada.; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, M5S 3E5, Canada.; Acceleration Consortium, University of Toronto, Toronto, ON, M5S 3H6, Canada.; Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada., Allen C; Intrepid Labs Inc., MaRS Centre, West Tower, 661 University Avenue Suite 1300, Toronto, ON, M5G 0B7, Canada.; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, M5S 3E5, Canada.; Acceleration Consortium, University of Toronto, Toronto, ON, M5S 3H6, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, M5S 3M2, Canada.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Nov; Vol. 13 (29), pp. e2401312. Date of Electronic Publication: 2024 Aug 18.
DOI: 10.1002/adhm.202401312
Abstrakt: Over the last four decades, pharmaceutical companies' expenditures on research and development have increased 51-fold. During this same time, clinical success rates for new drugs have remained unchanged at about 10 percent, predominantly due to lack of efficacy and/or safety concerns. This persistent problem underscores the need to innovate across the entire drug development process, particularly in drug formulation, which is often deprioritized and under-resourced.
(© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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