An epigenome-wide study of selenium status and DNA methylation in the Strong Heart Study.

Autor: Lieberman-Cribbin W; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA. Electronic address: wfl2112@cumc.columbia.edu., Domingo-Relloso A; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, USA., Glabonjat RA; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA., Schilling K; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA., Cole SA; Population Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA., O'Leary M; Missouri Breaks Industries Research, Cheyenne River Sioux Tribe, Eagle Butte, SD 57625, USA., Best LG; Missouri Breaks Industries Research, Cheyenne River Sioux Tribe, Eagle Butte, SD 57625, USA., Zhang Y; Department of Biostatistics and Epidemiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Fretts AM; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Umans JG; MedStar Health Research Institute, Hyattsville, MD, USA; Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC, USA., Goessler W; Institute of Chemistry, University of Graz, Graz, Austria., Navas-Acien A; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA., Tellez-Plaza M; Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Instituto de Salud Carlos III, 28029, Madrid, Spain., Kupsco A; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2024 Sep; Vol. 191, pp. 108955. Date of Electronic Publication: 2024 Aug 14.
DOI: 10.1016/j.envint.2024.108955
Abstrakt: Background: Selenium (Se) is an essential nutrient linked to adverse health endpoints at low and high levels. The mechanisms behind these relationships remain unclear and there is a need to further understand the epigenetic impacts of Se and their relationship to disease. We investigated the association between urinary Se levels and DNA methylation (DNAm) in the Strong Heart Study (SHS), a prospective study of cardiovascular disease (CVD) among American Indians adults.
Methods: Selenium concentrations were measured in urine (collected in 1989-1991) using inductively coupled plasma mass spectrometry among 1,357 participants free of CVD and diabetes. DNAm in whole blood was measured cross-sectionally using the Illumina MethylationEPIC BeadChip (850 K) Array. We used epigenome-wide robust linear regressions and elastic net to identify differentially methylated cytosine-guanine dinucleotide (CpG) sites associated with urinary Se levels.
Results: The mean (standard deviation) urinary Se concentration was 51.8 (25.1) μg/g creatinine. Across 788,368 CpG sites, five differentially methylated positions (DMP) (hypermethylated: cg00163554, cg18212762, cg11270656, and hypomethylated: cg25194720, cg00886293) were significantly associated with Se in linear regressions after accounting for multiple comparisons (false discovery rate p-value: 0.10). The top hypermethylated DMP (cg00163554) was annotated to the Disco Interacting Protein 2 Homolog C (DIP2C) gene, which relates to transcription factor binding. Elastic net models selected 425 hypo- and hyper-methylated DMPs associated with urinary Se, including three sites (cg00163554 [DIP2C], cg18212762 [MAP4K2], cg11270656 [GPIHBP1]) identified in linear regressions.
Conclusions: Urinary Se was associated with minimal changes in DNAm in adults from American Indian communities across the Southwest and the Great Plains in the United States, suggesting that other mechanisms may be driving health impacts. Future analyses should explore other mechanistic biomarkers in human populations, determine these relationships prospectively, and investigate the potential role of differentially methylated sites with disease endpoints.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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