| Autor: |
Khor CS; Tropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Malaysia., Lee HY; Tropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Malaysia., Abd-Majid MA; Tropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Malaysia., Khoo HY; Tropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Malaysia., Khoo JJ; Institute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., AbuBakar S; Tropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Malaysia. |
| Jazyk: |
angličtina |
| Zdroj: |
Tropical biomedicine [Trop Biomed] 2024 Jun 01; Vol. 41 (2), pp. 224-229. |
| DOI: |
10.47665/tb.41.2.015 |
| Abstrakt: |
Serological evidence has shown the presence of several mosquito-borne arbovirus infections among the inhabitants of the forest fringe areas of the tropics. Among these infections, Japanese encephalitis, dengue fever, chikungunya fever and Zika fever could be targeted for vaccination to overcome severe infection and limit the disease transmission. Seroprevalence data among this high-risk population are needed to provide an estimate of the potential cost-effectiveness of any vaccine programme targeting these infections. The present study was conducted at six indigenous people (Orang Asli) villages and FELDA (Federal Land Development Authority) settlements located at the forest fringes of Malaysia. All participants consented and provided blood samples and demographic data for the study. The blood samples were tested for the presence of antibodies against CHIKV, DENV, JEV and ZIKV individually using ELISA. Results obtained were also analysed to determine the predictors for CHIKV, DENV, JEV and ZIKV seropositivity. Among the 585 samples tested, 33.0% (N=193), 41.7% (N=244), 10.3% (N=60) and 21.0% (N=123) were positive for CHIKV IgG, DENV IgG, JEV IgG and ZIKV IgG, respectively. Approximately one-third (N=220, 37.6%) of the participants were tested negative for IgG antibodies against all four arboviruses. Age of participants and type of settlement were found to be a significant predictor for CHIKV, DENV, JEV and ZIKV seropositivity. Level of education was a significant predictor for CHIKV, DENV and ZIKV seropositivity. Gender, however, was not found to be a significant predictor for infection with any of these viruses. These findings reaffirmed the significant presence of infection involving these major arboviruses among the group of people living within the forest fringe areas of Peninsular Malaysia. Hence, any future consideration of vaccination for these infections must take into consideration the marginalized and underserved communities living at the forest fringe areas of the tropics where these infections are present. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
