| Autor: |
Chua HS; Department of Pathology, Hospital Melaka, Jalan Mufti Haji Khalil, 75400 Melaka, Malaysia., Soh YH; Centers for Disease Control and Prevention, Health District Office Melaka Tengah, Jalan Bukit Baru, 75150 Melaka, Malaysia.; Tropical Infectious Diseases Research & Education Centre, Higher Institution Centre of Excellence, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.; Department of Social and Preventive Medicine, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia., Ibrahim S; Department of Pathology, Hospital Melaka, Jalan Mufti Haji Khalil, 75400 Melaka, Malaysia., Abdullah NH; Department of Pathology, Hospital Melaka, Jalan Mufti Haji Khalil, 75400 Melaka, Malaysia., Che Mat Seri NAA; Tropical Infectious Diseases Research & Education Centre, Higher Institution Centre of Excellence, Universiti Malaya, 50603 Kuala Lumpur, Malaysia., AbuBakar S; Tropical Infectious Diseases Research & Education Centre, Higher Institution Centre of Excellence, Universiti Malaya, 50603 Kuala Lumpur, Malaysia., Loong SK; Tropical Infectious Diseases Research & Education Centre, Higher Institution Centre of Excellence, Universiti Malaya, 50603 Kuala Lumpur, Malaysia. |
| Abstrakt: |
Vibrio vulnificus infection is associated with high morbidity and mortality in high-risk patients. Poor prognoses could lead to >50% mortality rate. The present report describes a case of V. vulnificus bacteremia in a cirrhotic patient with underlying hepatitis C. He presented with generalised abdominal pain associated with distention and could not ambulate for one week. He also complained of fever for six days and pruritus for 10 days. Tea-coloured urine was noted in continuous bag drainage. The abdomen was distended but soft, with mild tenderness palpated over the left lumbar and iliac region. Blood investigation indicated ongoing infection and inflammation. The aerobic blood culture was identified using the matrix-assisted laser desorption/ionisation-time of flight mass spectrometry and confirmed via 16S rDNA sequencing as V. vulnificus. Multilocus sequence typing of the isolated V. vulnificus revealed a novel sequence type, ST540. The patient responded well to the intravenous cefoperazone and was then discharged with a four day-course of oral ciprofloxacin, 500 mg twice daily after completing the intravenous cefoperazone for 10 days. Clinical history and physical examination are important for early antibiotic therapy initiation and appropriate surgical intervention. Furthermore, bacterial strain typing is also essential for epidemiological surveillance and potentially anticipating the pathogen's virulence traits, which are vital in controlling and preventing the spread of infection. |
