Aspirin but not statins is inversely related to gastric cancer with a duration-risk effect: Results from the Stomach Cancer Pooling Project Consortium.

Autor: Pastorino R; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Pires Marafon D; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy., Sassano M; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Hoxhaj I; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy., Pelucchi C; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Liao LM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA., Rabkin CS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA., Sinha R; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA., Lunet N; Unidade de Investigação em Epidemiologia, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.; Laboratório Para a Investigação Integrativa e Translacional em Saúde Populacional, Universidade do Porto, Porto, Portugal.; Department of Clinical Epidemiology, N. N. Blokhin National Medical Research Center for Oncology, Moscow, Russia., Morais S; Unidade de Investigação em Epidemiologia, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.; Laboratório Para a Investigação Integrativa e Translacional em Saúde Populacional, Universidade do Porto, Porto, Portugal., Zaridze D; Department of Clinical Epidemiology, N. N. Blokhin National Medical Research Center for Oncology, Moscow, Russia., Maximovich D; Department of Clinical Epidemiology, N. N. Blokhin National Medical Research Center for Oncology, Moscow, Russia., Aragonés N; Cancer Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain., Castaño-Vinyals G; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Barcelona Institute for Global Health, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., Gómez-Acebo I; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Faculty of Medicine, University of Cantabria, Santander, Spain.; Instituto de Investigación Sanitaria Valdecilla, Santander, Spain., López-Carrillo L; Mexico National Institute of Public Health, Morelos, Mexico., López-Cervantes M; Facultad de Medicina, Universidad Nacional Autónoma de México, Coyoacán, Mexico., Bonzi R; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Turati F; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Boffetta P; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.; Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA., Camargo MC; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA., Curado MP; Centro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo, Brazil., Vioque J; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernandez, Alicante, Spain., Zhang ZF; Department of Epidemiology, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA., Negri E; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., La Vecchia C; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Boccia S; Section of Hygiene, University Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Jazyk: angličtina
Zdroj: Cancer [Cancer] 2024 Dec 15; Vol. 130 (24), pp. 4276-4286. Date of Electronic Publication: 2024 Aug 18.
DOI: 10.1002/cncr.35510
Abstrakt: Background: Aspirin and statins have been suggested to have potential chemopreventive effects against gastric cancer (GC), although the results of previous studies have been inconsistent. This study therefore aimed to investigate the association between the use of aspirin and statins and GC.
Methods: A pooled analysis of seven case-control studies within the Stomach Cancer Pooling Project, including 3220 cases and 9752 controls, was conducted. Two-stage modeling analyses were used to estimate the association between aspirin and statin use and GC after adjusting for potential confounders.
Results: The pooled odds ratio (OR) of GC for aspirin users versus nonusers was 0.72 (95% confidence interval [CI], 0.54-0.95). The protective effect of aspirin appeared stronger in individuals without a GC family history (OR, 0.60; 95% CI, 0.37-0.95), albeit with borderline heterogeneity between those with and without a family history (p = .064). The OR of GC decreased with increasing duration of aspirin use, with an OR of 0.41 (95% CI, 0.18-0.95) for durations of ≥15 years. An inverse, nonsignificant association with the risk of GC was observed for the use of statins alone (OR, 0.79; 95% CI, 0.52-1.18).
Conclusions: These findings suggest that aspirin use, particularly long-term use, is associated with a reduced risk of GC, whereas a similar association was not observed with statins, possibly because of the low frequency of use.
(© 2024 The Author(s). Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.)
Databáze: MEDLINE
Externí odkaz: