Methylxanthine use in infants with hypoxic-ischemic encephalopathy: a retrospective cohort study.

Autor: Laughon ME; Department of Pediatrics, UNC School of Medicine, The University of North Carolina at Chapel Hill, Campus Box #7596, Chapel Hill, NC, 27599-7596, USA., Johnson JK; Department of Pediatrics, UNC School of Medicine, The University of North Carolina at Chapel Hill, Campus Box #7596, Chapel Hill, NC, 27599-7596, USA., Greenberg RG; Department of Pediatrics, Duke University, Durham, NC, USA., Clark RH; Pediatrix Center for Research, Education, Quality, and Safety, Sunrise, FL, USA., Jackson WM; Department of Pediatrics, UNC School of Medicine, The University of North Carolina at Chapel Hill, Campus Box #7596, Chapel Hill, NC, 27599-7596, USA. wesley.jackson@unc.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Aug 17; Vol. 14 (1), pp. 19082. Date of Electronic Publication: 2024 Aug 17.
DOI: 10.1038/s41598-024-70410-w
Abstrakt: Therapeutic hypothermia is the standard treatment for hypoxic-ischemic encephalopathy (HIE), but despite its widespread use, the rates of mortality and neurodevelopmental impairment for moderate to severe HIE remain around 30%. Methylxanthines, such as caffeine and aminophylline, have potential neuroprotective effects in the setting of hypoxic-ischemic injury. However, data on the safety and efficacy of methylxanthines in the setting of therapeutic hypothermia for HIE are limited. This retrospective multicenter study examined in-hospital outcomes in 52 infants with HIE receiving methylxanthines and therapeutic hypothermia. The frequency of mortality and in-hospital morbidities were similar to those of infants enrolled in clinical trials undergoing therapeutic hypothermia without adjunctive therapies. Clinical trials of methylxanthines for neuroprotection in HIE are needed to determine safety and efficacy and should explore optimal dosing and timing of methylxanthine administration.
(© 2024. The Author(s).)
Databáze: MEDLINE
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