Synthesis of cholesterol analogues and comparison on their effect on plasma cholesterol with β-Sitosterol.

Autor: Zhu H; School of Food Science and Engineering / Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan, Guangdong, China; School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China., Chen L; Shenzhen Bay Laboratory Pingshan Translational Medicine Center, Shenzhen, China., Chen ZX; School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China., Lin H; School of Food Science and Engineering / Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan, Guangdong, China., Liu J; College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing, China., Kwek E; School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China., Ma KY; School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China., He W; School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China., Wang G; WWHS Biotech, Inc., Shenzhen, China., Chen ZY; School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. Electronic address: zhenyuchen@cuhk.edu.hk.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2024 Dec 15; Vol. 461, pp. 140820. Date of Electronic Publication: 2024 Aug 13.
DOI: 10.1016/j.foodchem.2024.140820
Abstrakt: The application of plant sterols in the treatment of hypercholesterolemia is promising. We hypothesize that plant sterols can reduce blood cholesterol because they have a side chain of at least three branches. Three cholesterol analogues were synthesized: CA0 (no side chain), CA3 (a 3‑carbon chain with one branch), and CA14 (a 14‑carbon side chain with two branches), and then compared their effect on blood cholesterol with that of β-sitosterol. Structurally, β-sitosterol has a 10‑carbon side chain with three branches. Results demonstrated that β-sitosterol could effectively reduce plasma total cholesterol (TC) by 20.3%, whereas CA0, CA3 and CA14 did not affect plasma TC in hypercholesterolemia hamsters. β-Sitosterol was absent in the plasma and liver, indicating it was not absorbed. We concluded that β-sitosterol with three branches had plasma TC-lowering activity. In contrast, cholesterol analogues with a side chain of two or fewer branches did not affect plasma cholesterol.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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