"A decade of candidaemia: A comprehensive analysis of prognosis and risk factors at a Belgian tertiary hospital".

Autor: Deckers C; Service of Clinical Microbiology, CHU UCL Namur and Université Catholique de Louvain, Rue Gaston Thérasse, 1, Godinne, Yvoir 5530 , Belgium. Electronic address: corentin.deckers@uclouvain.be., Bélik F; Service of Clinical Microbiology, CHU UCL Namur and Université Catholique de Louvain, Rue Gaston Thérasse, 1, Godinne, Yvoir 5530 , Belgium., Khourssaji M; Service of Clinical Microbiology, CHU UCL Namur and Université Catholique de Louvain, Rue Gaston Thérasse, 1, Godinne, Yvoir 5530 , Belgium., Plum PE; Service of Infectious Disease, CHU UCL Namur and Université Catholique de Louvain, Yvoir, Belgium., Ausselet N; Service of Infectious Disease, CHU UCL Namur and Université Catholique de Louvain, Yvoir, Belgium., Bulpa P; Service of Intensive Care, CHU UCL Namur and Université Catholique de Louvain, Yvoir, Belgium., Sonet A; Service of Hematology, CHU UCL Namur and Université Catholique de Louvain, Yvoir, Belgium., Bihin B; Scientific Support Unit (USS), CHU UCL Namur and Université Catholique de Louvain, Yvoir, Belgium., Huang TD; Service of Clinical Microbiology, CHU UCL Namur and Université Catholique de Louvain, Rue Gaston Thérasse, 1, Godinne, Yvoir 5530 , Belgium., Denis O; Service of Clinical Microbiology, CHU UCL Namur and Université Catholique de Louvain, Rue Gaston Thérasse, 1, Godinne, Yvoir 5530 , Belgium., Montesinos I; Service of Clinical Microbiology, CHU UCL Namur and Université Catholique de Louvain, Rue Gaston Thérasse, 1, Godinne, Yvoir 5530 , Belgium.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2024 Nov; Vol. 110 (3), pp. 116493. Date of Electronic Publication: 2024 Aug 13.
DOI: 10.1016/j.diagmicrobio.2024.116493
Abstrakt: Candidemia, predominantly caused by C. albicans, poses a significant threat in hospitals. Yet, non-albicans candidemia (NAC) and antifungal resistance are increasing concerns. This retrospective study at CHU UCL Namur Mont-Godinne, a Belgian university hospital, from January 2013 to February 2023, analyzed 148 candidemia cases. The mean annual incidence was 0.94 per 1000 admissions, with a notable surge in C. albicans cases in 2020, possibly due to COVID-19. Candidemia was most prevalent in the ICU (48 %), with C. albicans (57.1 %) and C. glabrata (18.4 %) being the predominant species and a 30-day mortality rate of 38 %. NAC was significantly higher in the hematology unit (81 %). Notably, no echinocandin resistance was observed, while fluconazoleresistance remained stable at 10 %. NAC was associated with azole resistance. This study provides a decade-long overview of candidemia at CHU UCL Namur Mont-Godinne, offering valuable insights into its epidemiology and clinical characteristics in Belgian hospital settings.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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