| Autor: |
Mohanta I; Department of Chemistry, National Institute of Technology Rourkela, Rourkela, Odisha 769008, India., Sahu N; Department of Chemistry, National Institute of Technology Rourkela, Rourkela, Odisha 769008, India., Guchhait C; Department of Chemistry, National Institute of Technology Rourkela, Rourkela, Odisha 769008, India., Kaur L; School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala, Punjab 147004, India., Mandal D; School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala, Punjab 147004, India., Adhikari B; Department of Chemistry, National Institute of Technology Rourkela, Rourkela, Odisha 769008, India. |
| Abstrakt: |
Introducing kosmotropic salts enhances protein stability and reduces solubility by withdrawing water from the protein surface, leading to 'salting out', a phenomenon we have mimicked in supramolecular polymers (SPs). Under the guidance of Ag + , folic acid (FA) self-assembled in water through slipped-stacking and hydrophobic interactions into elongated, robust one-dimensional SPs, resulting in thermo-stable supergels. The SPs exhibited temperature and dilution tolerance, attributed to the stability of the FA-Ag + complex and its hydrophobic stacking. Importantly, FA-Ag + SP's stability has been augmented by the kosmotropic anions, such as SO 4 2- , strengthening hydrophobic interactions in the SP, evident from the enhanced J-band, causing improvement of gel's mechanical property. Interestingly, higher kosmotrope concentrations caused a significant decrease in SP's solubility, leading to precipitation of the reinforced SPs─a 'salting out' effect. Conversely, chaotropes like ClO 4 - slightly destabilized hydrophobic stacking and promoted an extended conformation of individual SP chain with enhanced solubility, resembling a 'salting in' effect. |
