Characteristics and causes of reported clozapine-related medication errors: analysis of the Ministry of Health database in Saudi Arabia.

Autor: AlAmri LS; Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, King Khalid International Airport, Airport Road, 11564, Riyadh, Saudi Arabia., Alluwaymi WS; Therapeutic Affairs Deputyship, Ministry of Health, Riyadh, Saudi Arabia., Alghamdi BG; Therapeutic Affairs Deputyship, Ministry of Health, Riyadh, Saudi Arabia., Alghanim RA; Therapeutic Affairs Deputyship, Ministry of Health, Riyadh, Saudi Arabia., Almordi AS; Therapeutic Affairs Deputyship, Ministry of Health, Riyadh, Saudi Arabia., Hettah RF; Therapeutic Affairs Deputyship, Ministry of Health, Riyadh, Saudi Arabia., Almushaikah SF; Therapeutic Affairs Deputyship, Ministry of Health, Riyadh, Saudi Arabia., AlShahrani AM; Therapeutic Affairs Deputyship, Ministry of Health, Riyadh, Saudi Arabia., Alshammri NT; Therapeutic Affairs Deputyship, Ministry of Health, Riyadh, Saudi Arabia., Aldossari SM; Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia., AlAwn LI; Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia., Alsaleh NA; Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, King Khalid International Airport, Airport Road, 11564, Riyadh, Saudi Arabia., AlShehri GH; Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, King Khalid International Airport, Airport Road, 11564, Riyadh, Saudi Arabia. ghalshehri@pnu.edu.sa.
Jazyk: angličtina
Zdroj: International journal of clinical pharmacy [Int J Clin Pharm] 2024 Dec; Vol. 46 (6), pp. 1410-1418. Date of Electronic Publication: 2024 Aug 17.
DOI: 10.1007/s11096-024-01782-2
Abstrakt: Background: Clozapine has shown great efficacy in treating treatment-resistant schizophrenia, but it is associated with a variety of medication- related safety problems. Despite this, there remains a lack of research on medication errors (MEs) associated with its use.
Aim: To characterize the nature and contributory factors of clozapine-related MEs reported from government hospitals and primary care centres in Saudi Arabia (SA).
Method: A cross-sectional analysis was carried out on MEs related to clozapine use reported to the General Administration of Pharmaceutical Care at the Ministry of Health (MOH) in Saudi Arabia between 2018 and 2022. The data were analysed descriptively to examine the nature and contributory factors of MEs.
Results: A total of 1,165 MEs were reported. The majority of reported errors involved patients aged > 18 years old, with 72.2% (n = 841) being male. The central region was found to report errors more frequently (32.3%, n = 376). Pharmacists were reported to detect errors most frequently (59.6%, n = 695). MEs most often occurred in the prescribing stage (77.8%, n = 906), with "missing prescription information" (30.1%, n = 351) being the most frequent finding. The most frequent contributing factor was the lack of policy (33.1%, n = 351). The majority of errors did not reach the patients (92.3%, n = 1,075), and those that did reach patients rarely resulted in harm (0.3%, n = 2).
Conclusion: This study identified areas for improvement which could expedite the development of remedial interventions to reduce the risk of errors.
Competing Interests: Conflicts of interest The authors have no conflicts of interest to declare.
(© 2024. The Author(s).)
Databáze: MEDLINE
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