Klotho: molecular mechanisms and emerging therapeutics in central nervous system diseases.

Autor: Hosseini L; Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. leilahosseini337@gmail.com., Babaie S; Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran., Shahabi P; Faculty of Medicine, Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran., Fekri K; Department of Paramedicine, Amol School of Paramedicine, Mazandaran University of Medical Sciences, Sari, Iran.; Preclinical Department, Amol Campus of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Shafiee-Kandjani AR; Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran., Mafikandi V; Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran., Maghsoumi-Norouzabad L; Research Center for Integrative Medicine in Aging, Tabriz University of Medical Sciences, Tabriz, Iran., Abolhasanpour N; Research Center for Evidence‑Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Jazyk: angličtina
Zdroj: Molecular biology reports [Mol Biol Rep] 2024 Aug 17; Vol. 51 (1), pp. 913. Date of Electronic Publication: 2024 Aug 17.
DOI: 10.1007/s11033-024-09862-2
Abstrakt: Klotho is recognized as an aging-suppressor protein that is implicated in a variety of processes and signaling pathways. The anti-inflammatory, anti-apoptotic, anti-oxidant, and anti-tumor bioactivities of klotho have extended its application in neurosciences and made the protein popular for its lifespan-extending capacity. Furthermore, it has been demonstrated that klotho levels would reduce with aging and numerous pathologies, particularly those related to the central nervous system (CNS). Evidence supports the idea that klotho can be a key therapeutic target in CNS diseases such as amyotrophic lateral sclerosis, Parkinson's disease, stroke, and Alzheimer's disease. Reviewing the literature suggests that the upregulation of klotho expression regulates various signaling pathways related to autophagy, oxidative stress, inflammation, cognition, and ferroptosis in neurological disorders. Therefore, it has been of great interest to develop drugs or agents that boost or restore klotho levels. In this regard, the present review was designed and aimed to gather the delegated documents regarding the therapeutic potential of Klotho in CNS diseases focusing on the molecular and cellular mechanisms.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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