Structural MRI findings in the brain related to pain distribution in chronic overlapping pain conditions: An explorative case-control study in females with fibromyalgia, temporomandibular disorder-related chronic pain and pain-free controls.

Autor: Lam J; Department of Orofacial Pain and Jaw Function, Faculty of Odontology, Malmö University, Malmö, Sweden.; General Dental Care, Folktandvården Skåne, Lund, Sweden.; Scandinavian Center for Orofacial Neurosciences, Malmö, Sweden., Mårtensson J; Division of Logopedics, Phoniatrics and Audiology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden., Westergren H; Department of Health Sciences, Lund University, Lund, Sweden., Svensson P; Department of Orofacial Pain and Jaw Function, Faculty of Odontology, Malmö University, Malmö, Sweden.; Scandinavian Center for Orofacial Neurosciences, Malmö, Sweden.; Section for Orofacial Pain and Jaw Function, Faculty of Health, Aarhus University, Aarhus, Denmark., Sundgren PC; Department of Medical Imaging and Physiology, Skåne University Hospital Lund University, Lund, Sweden.; Division of Radiology, Department of Clinical Sciences, Lund University, Lund, Sweden.; Lund University BioImaging Center, Lund University, Lund, Sweden.; Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA., Alstergren P; Department of Orofacial Pain and Jaw Function, Faculty of Odontology, Malmö University, Malmö, Sweden.; Scandinavian Center for Orofacial Neurosciences, Malmö, Sweden.; Specialised Pain Rehabilitation, Skåne University Hospital, Lund, Sweden.
Jazyk: angličtina
Zdroj: Journal of oral rehabilitation [J Oral Rehabil] 2024 Nov; Vol. 51 (11), pp. 2415-2426. Date of Electronic Publication: 2024 Aug 16.
DOI: 10.1111/joor.13842
Abstrakt: Background: Few neuroimaging studies have investigated structural brain differences associated with variations in pain distribution.
Objective: To explore structural differences of the brain in fibromyalgia (FM), temporomandibular disorder pain (TMD) and healthy pain-free controls (CON) using structural and diffusion MRI.
Methods: A case-control exploratory study with three study groups with different pain distribution were recruited: FM (n = 16; mean age [standard deviation]: 44 [14] years), TMD (n = 17, 39 [14] years) and CON (n = 10, 37 [14] years). Participants were recruited at the University Dental Clinic in Malmö, Sweden. T1-weighted and diffusion MRIs were acquired, clinical and psychosocial measures were obtained. Main outcome measures were subcortical volume, cortical thickness, white matter microstructure and whole brain grey matter intensity.
Results: Patients with FM had smaller volume in the right thalamus than patients with TMD (p = .020) and CON (p = .030). The right thalamus volume was negatively correlated to pain intensity (r = -0.37, p = .022) and pain-related disability (r = -0.45, p = .004). The FM group had lower cortical thickness in the right anterior prefrontal cortex than CON (p = .005). Cortical thickness in this area was negatively correlated to pain intensity (r [37] = - 0.48, p = .002).
Conclusions: This study suggests that thalamus grey matter alterations are associated with FM and TMD, and that anterior prefrontal cortex grey matter alterations are associated with FM but not TMD. Studies on chronic overlapping pain conditions are needed in relation to possible nociplastic pain mechanisms in the brain and central nervous system.
(© 2024 The Author(s). Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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