The role of Lin28A and Lin28B in cancer beyond Let-7.

Autor: Cotino-Nájera S; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Mexico City, Mexico., García-Villa E; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Mexico City, Mexico., Cruz-Rosales S; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Mexico City, Mexico., Gariglio P; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Mexico City, Mexico., Díaz-Chávez J; Departamento de Biología Celular, Facultad de Ciencias, UNAM, Mexico City, Mexico.; Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, UNAM/Instituto Nacional de Cancerología, Mexico City, Mexico.; Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico.
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 2024 Dec; Vol. 598 (24), pp. 2963-2979. Date of Electronic Publication: 2024 Aug 16.
DOI: 10.1002/1873-3468.15004
Abstrakt: Lin28A and Lin28B are paralogous RNA-binding proteins that play fundamental roles in development and cancer by regulating the microRNA family of tumor suppressor Let-7. Although Lin28A and Lin28B share some functional similarities with Let-7 inhibitors, they also have distinct expression patterns and biological functions. Increasing evidence indicates that Lin28A and Lin28B differentially impact cancer stem cell properties, epithelial-mesenchymal transition, metabolic reprogramming, and other hallmarks of cancer. Therefore, it is important to understand the overexpression of Lin28A and Lin28B paralogs in specific cancer contexts. In this review, we summarize the main similarities and differences between Lin28A and Lin28B, their implications in different cellular processes, and their role in different types of cancer. In addition, we provide evidence of other specific targets of each lin28 paralog, as well as the lncRNAs and miRNAs that promote or inhibit its expression, and how this impacts cancer development and progression.
(© 2024 The Author(s). FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
Databáze: MEDLINE
Externí odkaz: