Child-parent associations of hematocrit in trios of Japanese adulthood confirmed by the random family method: The TMM BirThree Cohort Study.

Autor: Usuzaki T; Department of Diagnostic Radiology, Tohoku University Hospital, Sendai, Japan., Ishikuro M; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan.; Division of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan., Kikuya M; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan.; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan., Murakami K; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan., Noda A; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan.; Division of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan., Ueno F; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan., Metoki H; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan.; Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Obara T; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan. obara-t@hosp.tohoku.ac.jp.; Division of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan. obara-t@hosp.tohoku.ac.jp.; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan. obara-t@hosp.tohoku.ac.jp., Kuriyama S; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8573, Japan.; Division of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.; Division of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Aug 16; Vol. 14 (1), pp. 19047. Date of Electronic Publication: 2024 Aug 16.
DOI: 10.1038/s41598-024-69752-2
Abstrakt: To examine child-parent associations of HCT among Japanese adults and their parents. Factors associated with hematocrit (HCT) were analyzed in 3,574 sons and 7,203 daughters using Pearson's correlation coefficient and Student's t-test. Multiple linear regression analysis, adjusted by the factors identified by univariate analyses and by living with parents, was performed on 242 son-parent trios and 587 daughter-parent trios. When a child-parent association was observed in the multiple linear regression analysis, it was validated using the random family method (RFM). In univariate analyses, the son's HCT was associated with age (correlation coefficient = -0.072), white blood cell (WBC) (0.19), alanine aminotransferase (ALT) (0.20), triglyceride (0.11), and estimated glomerular filtration rate (eGFR) (- 0.087). The daughter's HCT was associated with WBC (0.014), ALT (0.18), and eGFR (- 0.17). In multiple linear regression analysis, the son's HCT was associated with the son's WBC (coefficient = 3.48 × 10 -4 ), the son's eGFR (0.031), the father's HCT (0.11), and the mother's HCT (0.17). RFM confirmed the association between the son's and father's HCT (p = 0.0070) and between the son's and mother's HCT (p = 0.0011). The daughter's HCT was associated with WBC (2.6 × 10 -4 ), ALT (0.037), and the mother's HCT (0.14). RFM confirmed the association between the daughter's and mother's HCT (p = 0.00043). Child-parent association of HCT was confirmed between son-father, son-mother, and daughter-mother relationships, and differed depending on the sex of the child and the parents.
(© 2024. The Author(s).)
Databáze: MEDLINE
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