Emerging Evidence and Critical Issues with the Use of Single-Drop Capillary Blood for the Measurement of Hemoglobin Concentration in Population-Level Anemia Surveys.

Autor:	Karakochuk CD; Food, Nutrition and Health, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, Canada., Dary O; Bureau for Global Health, Maternal and Chid Health and Nutrition Office, USAID, Washington, D.C., United States., Flores-Urrutia MC; Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland., Garcia-Casal MN; Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland., Hayashi C; Data & Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, United States., Jefferds MED; Nutrition Branch, Division of Nutrition, Physical Activity and Obesity, Centers for Disease Control and Prevention, Atlanta, GA, United States., Johnston R; Data & Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, United States., Larson LM; Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States., Mapango C; Nutrition Branch, Division of Nutrition, Physical Activity and Obesity, Centers for Disease Control and Prevention, Atlanta, GA, United States., Mazariegos Cordero DI; Nutrition and Micronutrient Department, Institute of Nutrition of Central America and Panamá, Guatemala City, Guatemala., Moorthy D; NuMERAL, RTI International, Washington, D.C., United States., Namaste S; NuMERAL, RTI International, Washington, D.C., United States., Rogers LM; Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland., Saha K; Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland., Wuehler S; Program Operations Unit, Nutrition International, Ottawa, Ontario, Canada. Electronic address: swuehler@nutritionintl.org.
Jazyk:	angličtina
Zdroj:	Advances in nutrition (Bethesda, Md.) [Adv Nutr] 2024 Oct; Vol. 15 (10), pp. 100290. Date of Electronic Publication: 2024 Aug 14.
DOI:	10.1016/j.advnut.2024.100290
Abstrakt:	Accurate and precise measurement of hemoglobin concentration is critical for reliable estimations of anemia prevalence at the population level. When systematic and/or random error are introduced in hemoglobin measurement, estimates of anemia prevalence might be significantly erroneous and, hence, limit their usefulness. For decades, single-drop capillary blood has been the most common blood source used for the measurement of hemoglobin concentration in surveys, especially in low-income and middle-income countries. In this study, we highlight historical and emerging evidence that single-drop capillary blood introduces a high degree of random error (variability) to hemoglobin estimates, leading to less reliable estimates of anemia prevalence at the population level. At present, the best practice is to collect and use venous blood for measurement of hemoglobin with an automated hematology analyzer, following standard operating procedures and quality assurance measures. Where use of an automated analyzer is not possible, the analysis of venous blood in a point-of-care hemoglobinometer by trained phlebotomists or specimen collectors should be considered. A forthcoming systematic review will provide additional evidence on the accuracy and precision of single-drop capillary blood for hemoglobin assessment. In the meantime, we raise caution when using single-drop capillary blood for hemoglobin measurement as it can result in inaccurate hemoglobin estimates and less reliable anemia prevalence estimates. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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