Temporal and Spatial Clustering of Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy.

Autor:	Fandler-Höfler S; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Ambler G; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Banerjee G; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Nash PS; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Obergottsberger L; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Wünsch G; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Kiss C; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Fabisch L; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Kneihsl M; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Zhang W; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Ozkan H; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Locatelli M; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Du Y; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Panteleienko L; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Mendel R; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Thiankhaw K; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Simister RJ; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Jäger HR; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Enzinger C; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Gattringer T; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom., Werring DJ; From the Department of Neurology (S.F.-H., L.O., C.K., L.F., M.K., C.E., T.G.), Medical University of Graz, Austria; Stroke Research Centre (S.F.-H., G.B., P.S.N., W.Z., H.O., M.L., Y.D., L.P., R.M., K.T., R.J.S., D.J.W.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology; Department of Statistical Science (G.A.), University College London; MRC Prion Unit at UCL (G.B.), Institute of Prion Diseases, London, United Kingdom; Institute for Medical Informatics, Statistics and Documentation (G.W.), and Division of Neuroradiology, Vascular and Interventional Radiology (M.K.), Department of Radiology, Medical University of Graz, Austria; and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.
Jazyk:	angličtina
Zdroj:	Neurology [Neurology] 2024 Sep 10; Vol. 103 (5), pp. e209770. Date of Electronic Publication: 2024 Aug 16.
DOI:	10.1212/WNL.0000000000209770
Abstrakt:	Objectives: Cerebral amyloid angiopathy (CAA)-associated lobar intracerebral hemorrhage (ICH) has a high risk of recurrence, but the underlying mechanisms remain uncertain. We, therefore, aimed to characterize patterns of recurrent ICH. Methods: We investigated early recurrent ICH (≥1 recurrent ICH event within 90 days of the index event) and ICH clusters (≥2 ICH events within 90 days at any time point) in 2 large cohorts of consecutive patients with first-ever ICH and available MRI. Results: In 682 included patients (median age 68 years, 40.3% female, median follow-up time 4.1 years), 18 (2.6%) had an early recurrent ICH, which was associated with higher age and CAA. In patients with probable CAA, the risk of early recurrent ICH was increased 5-fold within the first 3 months compared with during months 4-12 (hazard ratio 5.41, 95% CI 2.18-13.4) while no significant difference was observed in patients without CAA. In patients with an ICH cluster, we observed spatial clustering (recurrent ICH within close proximity of index ICH in 63.0%) and a tendency for multiple sequential hemorrhages (≥3 ICH foci within 3 months in 44.4%). Discussion: Our data provide evidence of both temporal and spatial clustering of ICH in CAA, suggesting a transient and localized active bleeding-prone process.
Databáze:	MEDLINE
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