| Autor: |
Tunca Arın TA; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, 128 00 Prague 2, Czech Republic., Sedlacek O; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, 128 00 Prague 2, Czech Republic. |
| Jazyk: |
angličtina |
| Zdroj: |
Biomacromolecules [Biomacromolecules] 2024 Sep 09; Vol. 25 (9), pp. 5630-5649. Date of Electronic Publication: 2024 Aug 16. |
| DOI: |
10.1021/acs.biomac.4c00833 |
| Abstrakt: |
Fluorine magnetic resonance imaging ( 19 F MRI) is a rapidly evolving research area with a high potential to advance the field of clinical diagnostics. In this review, we provide an overview of the recent progress in the field of fluorinated stimuli-responsive polymers applied as 19 F MRI tracers. These polymers respond to internal or external stimuli (e.g., temperature, pH, oxidative stress, and specific molecules) by altering their physicochemical properties, such as self-assembly, drug release, and polymer degradation. Incorporating noninvasive 19 F labels enables us to track the biodistribution of such polymers. Furthermore, by triggering polymer transformation, we can induce changes in 19 F MRI signals, including attenuation, amplification, and chemical shift changes, to monitor alterations in the environment of the tracer. Ultimately, this review highlights the emerging potential of stimuli-responsive fluoropolymer 19 F MRI tracers in the current context of polymer diagnostics research. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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