Cancer risk by length of Barrett's esophagus in Japanese population: a nationwide multicenter retrospective cohort study.

Autor: Fukuda S; Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan., Watanabe K; Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan., Kubota D; Next-Generation Endoscopic Computer Vision, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Yamamichi N; Center for Epidemiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan., Takahashi Y; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Watanabe Y; Department of Gastroenterology, Kameda Medical Center Makuhari, Chiba, Chiba, Japan., Adachi K; Health Center, Shimane Environment and Health Public Corporation, Matsue, Shimane, Japan., Ishimura N; Second Department of Internal Medicine, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan., Koike T; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan., Sugawara H; Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan., Asanuma K; Cancer Detection Center, Miyagi Cancer Society, Sendai, Miyagi, Japan., Abe Y; Division of Endoscopy, Yamagata University Hospital, Yamagata, Yamagata, Japan., Kon T; Department of Gastroenterology, Yamagata Saisei Hospital, Yamagata, Yamagata, Japan., Ihara E; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan., Haraguchi K; Department of Gastroenterology, Harasanshin Hospital, Fukuoka, Fukuoka, Japan., Otsuka Y; Department of Gastroenterology, Harasanshin Hospital, Fukuoka, Fukuoka, Japan., Yoshimura R; Medical Treatment Corporate Foundation Group Hakuaikai Medical Checkup Center Wellness, Fukuoka, Fukuoka, Japan., Iwaya Y; Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.; Department of Gastroenterology, Aizawa Hospital, Matsumoto, Nagano, Japan., Okamura T; Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.; Department of Gastroenterology, Aizawa Hospital, Matsumoto, Nagano, Japan., Manabe N; Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan., Horiuchi A; Digestive Disease Center, Showa Inan General Hospital, Komagane, Nagano, Japan., Matsumoto M; Department of Gastroenterology, Sapporo Medical Center, NTT EC, Sapporo, Hokkaido, Japan.; Department of Gastroenterology, Sapporo Cancer Screening Center, Public Interest Foundation Hokkaido Cancer Society, Sapporo, Hokkaido, Japan., Onochi K; Department of Gastroenterology, Omagari Kosei Medical Center, Omagari, Akita, Japan., Takahashi S; Department of Gastroenterology, Yuri Kumiai General Hospital, Yurihonjo, Akita, Japan., Yoshida T; Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan., Shimodaira Y; Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan., Iijima K; Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan. kiijima@med.akita-u.ac.jp.
Jazyk: angličtina
Zdroj: Journal of gastroenterology [J Gastroenterol] 2024 Oct; Vol. 59 (10), pp. 887-895. Date of Electronic Publication: 2024 Aug 16.
DOI: 10.1007/s00535-024-02139-2
Abstrakt: Background: The cancer risk for each length of Barrett's esophagus (BE) in Japanese is unknown. This nationwide, multi-institutional study aims to clarify the cancer risk by length of BE in the general Japanese population.
Methods: Consecutive subjects who underwent upper endoscopic screening at 17 centers between 2013 and 2017 and had at least one follow-up endoscopy by December 2022 were included. The presence/absence of BE and, if present, its length were retrospectively assessed using the retrieved endoscopic images recorded at baseline. Information on the subsequent occurrence of esophageal adenocarcinoma and other upper gastrointestinal cancers was also collected. Cancer incidence was calculated and expressed as %/year.
Results: A total of 33,478 subjects were enrolled, and 17,884 (53.4%), 10,641 (31.8%), 4889 (14.6%), and 64 (0.2%) were diagnosed as absent BE, BE < 1 cm, 1-3 cm, and ≥ 3 cm, respectively. During a median follow-up of 80 months, 11 cases of esophageal adenocarcinoma developed. The annual incidence of esophageal adenocarcinoma is 0%/year for absent BE, 0.0032 (0.00066-0.013)%/year for BE < 1 cm, 0.026 (0.011-0.054)%/year for 1-3 cm, and 0.58 (0.042-2.11)%/year for ≥ 3 cm, respectively. Meanwhile, the incidence of esophageal squamous cell carcinoma and gastric cancer were 0.039 (0.031-0.049)%/year and 0.16 (0.14-0.18)%/year, respectively.
Conclusions: By enrolling a large number of subjects with long-term follow-up, this study demonstrated that the risk of cancer increased steadily with increasing length of BE in the Japanese population. Therefore, it is important to consider the length of BE when determining the management strategy for BE.
(© 2024. Japanese Society of Gastroenterology.)
Databáze: MEDLINE
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