Conjugated Linoleic Acid in Cancer Therapy.

Autor:	George J; Department of Integrative Biology, School of Bioscience and Technology (SBST), Vellore Institute of Technology (VIT), Vellore-632014, Tamil Nadu, India., Ghosh AR; Department of Integrative Biology, School of Bioscience and Technology (SBST), Vellore Institute of Technology (VIT), Vellore-632014, Tamil Nadu, India.
Jazyk:	angličtina
Zdroj:	Current drug delivery [Curr Drug Deliv] 2024 Aug 15. Date of Electronic Publication: 2024 Aug 15.
DOI:	10.2174/0115672018325362240811164655
Abstrakt:	Conjugated Linoleic Acid (CLA) is a polyunsaturated dietary fatty acid. Probiotics can biohydrogenate CLA with multiple health benefits, especially in cancer treatment. In vitro, in vivo, and clinical studies have confirmed CLA isomers to possess anti-cancer activity. CLA has demonstrated its potential as an alternative treatment for cancer and also used as an adjuvant to reduce the side effects of existing treatment methods. The mechanism of the anticancer activity of CLA is still not clear; however, it may involve intervention with the cell cycle and modulation of gene expression. A greater potential of CLA for cancer treatment has been supported by more and more clinical trials to evaluate its potential. Some advanced technologies are in progress to overcome the flaws of current methods and enhance the microbial production of CLA. In conclusion, nutritional enrichment as a functional food and direct consumption of CLA may contribute to cancer management. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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