Replication forks associated with long nuclear actin filaments in mild stress conditions display increased dynamics.
| Autor: | Merigliano C; Molecular and Computational Biology Department, University of Southern California, Los Angeles, United States., Palumbieri MD; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Lopes M; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Chiolo I; Molecular and Computational Biology Department, University of Southern California, Los Angeles, United States. |
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| Jazyk: | angličtina |
| Zdroj: | MicroPublication biology [MicroPubl Biol] 2024 Jul 31; Vol. 2024. Date of Electronic Publication: 2024 Jul 31 (Print Publication: 2024). |
| DOI: | 10.17912/micropub.biology.001259 |
| Abstrakt: | Nuclear actin filaments (F-actin) form during S-phase and in response to replication stress to promote fork remodeling and repair. In mild replication stress conditions, nuclear actin polymerization is required to limit PrimPol recruitment to the fork while promoting fork reversal. Both short and long filaments form during this response, but their function in the nuclear dynamics of replication sites was unclear. Here, we show that replication centers associated with long nuclear actin filaments become more mobile than the rest of the forks, suggesting relocalization of replication sites as a response to prolonged fork stalling and/or fork breakage, even in response to mild replication stress. Competing Interests: The authors declare that there are no conflicts of interest present. (Copyright: © 2024 by the authors.) |
| Databáze: | MEDLINE |
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