The Role of Coenzyme Q10 in Skin Aging and Opportunities for Topical Intervention: A Review.
| Autor: | Lain ET; Dr. Lain is with Sanova Dermatology in Austin, Texas., Agrawal N; Messrs. Agrawal and Ruvolo are with Beiersdorf, Inc, IC in Florham Park, New Jersey., Ruvolo E; Messrs. Agrawal and Ruvolo are with Beiersdorf, Inc, IC in Florham Park, New Jersey., Weise JM; Dr. Weise is with Beiersdorf AG, Research and Development in Hamburg, Germany., Callender VD; Dr. Callender is with the Callendar Dermatology and Cosmetic Center in Glenn Dale, Maryland. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of clinical and aesthetic dermatology [J Clin Aesthet Dermatol] 2024 Aug; Vol. 17 (8), pp. 50-55. |
| Abstrakt: | Background: Coenzyme Q10 (CoQ10) is a naturally produced, lipid-soluble molecule crucial for cellular energy production and antioxidant activity. It diminishes with age and under external stress factors in skin, leading to signs of aging. Beyond its role in cellular energy production within the mitochondria, CoQ10 is vital to skin's defense against oxidative stress, a key contributor to premature aging. Use of topical skincare products with CoQ10 can be effective to replenish levels of CoQ10 and reverse skin aging. Objective: This publication discusses the role of CoQ10 in skin aging along with the benefits of topical skincare products that incorporate CoQ10 as an ingredient. Methods: We searched the PubMed database using terms "Coenzyme Q10" and "skin" and "aging." Overall, the search yielded 80 results, but a limitation of 10 years was then applied to restrict publications to those with the most up-to-date science. Results: A total of 36 publications were identified and included as background for this article. These 36 publications encompassed both original research articles and review articles. Discussion: Applying topical skincare products with CoQ10 replenishes CoQ10 cellular levels, helping to normalize cellular energy homeostasis and providing antioxidative effects to support and repair cutaneous damage including signs of skin aging. In ex vivo and in vivo studies, application of CoQ10 increased CoQ10 levels both on the skin surface (i.e., stratum corneum) and even more in deeper levels of the skin. Clinically, topical application of CoQ10-formulated products reduces the depth of cutaneous wrinkles, a sign associated with aging. Conclusion: Aging and stressed skin are, in part, the result of alterations in cellular metabolic homeostasis, which can be reversed via the benefits of topical application of CoQ10-enriched formulations that stimulate cutaneous energy metabolism and reduce free radicals via antioxidant function. By restoring physiological homeostasis, topical skincare products with CoQ10 replenish the skin's antioxidant levels, increase cellular (energy) metabolism, and reduce the signs of skin aging. Competing Interests: DISCLOSURES: Dr. Lain has served as consultant and/or investigator for AbbVie, Aclaris Therapeutics Inc., AlfaSigma, Allergan Inc., Almirall, Arcutis, AstraZeneca, Athenix, Biofrontera, Biopelle Inc., BioPharmX, Biorasi LLC, Bristol Myers Squibb, Brickell Biotech Inc., Cassiopea S.p.A., Castle Biosciences, Celgene, Cellceutix, ChemoCentryx, Concert Pharma, Cutanea Life Sciences, Demira, Dermavant, Dermtech, Dow Pharmaceutical Sciences Inc., Dr Reddy’s Laboratory, Eli Lily, EPI Health, Endo Pharma, Evelo, Gage Development Company LLC, Galderma Laboratories, LP, Hovione, Incyte, Janssen, Johnson & Johnson, Kadmon Corporation LLC, La Roche-Posay Laboratorie Pharmaceutique, LEO Laboratories Ltd., Medimmune, Menlo Therapeutics, Mindera, Neothetics, Nielsen Holdings NV, Novartis, Ortho Dermatologics, Pierre Fabre, Pfizer Inc, Promius Pharma LLC, Sanofi, Sebacia Inc., Sienna Labs Inc., SkinCeuticals LLC, Sol-Gel Technologies, SUN Pharma, Symatese Timber Pharma, UCB, Valeant Pharmaceuticals North America LLC, and Vyne Therapeutics, and is a stockholder in Moleculin LLC; Agrawal, Ruvolo, and Dr. Weise are employees of Beiersdorf; Dr. Callender has served as an investigator and/or received grants from AbbVie/Allergan, Almirall, Aerolase, Arcutis, Avava, Beiersdorf, Eirion, Eli Lilly, Janssen, L’Oréal, Pfizer, Prollenium, Skinbetter Science, Symatese, Teoxane; as a consultant or advisor for Acne Store, Aerolase, Arcutis, Avita Medical, Beiersdorf, Cutera, Dermavant, EPI Health, Jeune Aesthetics, L’Oréal, OrthoDerm, Scientis, Sente, SkinCeuticals, UCB; as a speaker for Eli Lilly, L’Oréal, SkinCeuticals; and has received royalties from Elsevier and UpToDate. (Copyright © 2024. Matrix Medical Communications. All rights reserved.) |
| Databáze: | MEDLINE |
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