The positive predictive value of MOG-IgG testing based on the 2023 diagnostic criteria for MOGAD.

Autor:	Nguyen L; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Singh S, Feltrin FS; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Tardo LM; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Clarke RL; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Wang CX; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Greenberg BM; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jazyk:	angličtina
Zdroj:	Multiple sclerosis journal - experimental, translational and clinical [Mult Scler J Exp Transl Clin] 2024 Aug 14; Vol. 10 (3), pp. 20552173241274610. Date of Electronic Publication: 2024 Aug 14 (Print Publication: 2024).
DOI:	10.1177/20552173241274610
Abstrakt:	Background: Myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) is a relatively new disease entity in the field of demyelinating disorders. Its first diagnostic criteria have recently been published. Objectives: We evaluated the positive predictive value (PPV) for MOG-IgG testing and report the clinical and radiologic features with respect to the recently published criteria. Methods: A retrospective study was conducted at three centers in Dallas, Texas. Patients with positive MOG-IgG testing on cell-based assays at any time were included. Positive cases were reviewed by at least two neuroimmunologists for fulfillment of the criteria. Results: We included 235 patients. The PPV of seropositivity at any time was 78.3% overall, 52.6% for low titer, and 90.1% for high titer. Children had a higher PPV than adults (93.9% versus 67.2%). Positive predictive value was 6.3% in those without a core clinical demyelinating attack. Children more often have the typical imaging features of MOGAD in optic neuritis than adults. Conclusions: We report a PPV of 78.3% for MOG-IgG testing using the 2023 MOGAD diagnostic criteria. Children had higher PPV and frequency of supporting imaging features. Careful consideration is necessary when assigning patients with no core demyelinating event and low titers a MOGAD diagnosis. Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s), 2024.)
Databáze:	MEDLINE
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