Cholic Acid/Glutathione-Assembled Nanofibrils for Stabilizing Pickering Emulsion Biogels.

Autor: Bi W; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China., Le M; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China., Jia YG; Center for Advanced Materials Research, Beijing Normal University, Zhuhai, 519087, China., Bao Z; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China., Sun S; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China., Wang C; School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China., Binks BP; Department of Chemistry, University of Hull, Hull, HU6 7RX, UK., Chen Y; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China.; School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.; Key Laboratory of Biomedical Engineering of Guangdong Province, andInnovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Nov; Vol. 20 (47), pp. e2403667. Date of Electronic Publication: 2024 Aug 15.
DOI: 10.1002/smll.202403667
Abstrakt: Achieving the delicate balance required for both emulsion and gel characteristics, while also imparting biological functionality in gelled emulsions, poses a significant challenge. Herein, we report on Pickering emulsion biogels formed by novel biological nanofibrils assembled from natural glutathione (GSH) and a tripod cholic acid derivative (TCA) via electrostatic interactions. GSH, composed of tripeptides with carboxyl groups, facilitates the protonation and dissolution of TCA compounds in water and the electrostatic interactions between GSH and TCA trigger nanofibrillar assembly. Fibrous nuclei initially emerge, and the formed mature nanofibrils can generate a stable hydrogel at a low solid concentration. These nanofibrils exhibit efficient emulsifying capability, enabling the preparation of stable Pickering oil-in-water (O/W) emulsion gels with adjustable phase volume ratios. The entangled nanofibrils adsorbed at the oil-water interface restrict droplet movement, imparting viscoelasticity and injectability to the emulsions. Remarkably, the biocompatible nanofibrils and stabilized emulsion gels demonstrate promising scavenging properties against reactive oxygen species (ROS). This strategy may open new scenarios for the design of advanced emulsion gel materials using natural precursors and affordable building blocks for biomedical applications.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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