Olfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking.

Autor: Takagi S; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. Suguru.Takagi@unil.ch., Sancer G; Department of Neuroscience, Yale University, New Haven, CT, USA., Abuin L; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Stupski SD; Department of Mechanical Engineering, University of Nevada, Reno, NV, USA., Roman Arguello J; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.; Department of Ecology and Evolution, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.; School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK., Prieto-Godino LL; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.; The Francis Crick Institute, London, UK., Stern DL; Janelia Research Campus of the Howard Hughes Medical Institute, Ashburn, VA, USA., Cruchet S; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Álvarez-Ocaña R; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Wienecke CFR; Department of Neurobiology, Stanford University, Stanford, CA, USA.; Department of Neurobiology, Harvard Medical School, Cambridge, MA, USA., van Breugel F; Department of Mechanical Engineering, University of Nevada, Reno, NV, USA., Jeanne JM; Department of Neuroscience, Yale University, New Haven, CT, USA., Auer TO; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. Thomas.Auer@unifr.ch.; Department of Biology, University of Fribourg, Fribourg, Switzerland. Thomas.Auer@unifr.ch., Benton R; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. Richard.Benton@unil.ch.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Aug 15; Vol. 15 (1), pp. 7041. Date of Electronic Publication: 2024 Aug 15.
DOI: 10.1038/s41467-024-50808-w
Abstrakt: The evolutionary expansion of sensory neuron populations detecting important environmental cues is widespread, but functionally enigmatic. We investigated this phenomenon through comparison of homologous olfactory pathways of Drosophila melanogaster and its close relative Drosophila sechellia, an extreme specialist for Morinda citrifolia noni fruit. D. sechellia has evolved species-specific expansions in select, noni-detecting olfactory sensory neuron (OSN) populations, through multigenic changes. Activation and inhibition of defined proportions of neurons demonstrate that OSN number increases contribute to stronger, more persistent, noni-odour tracking behaviour. These expansions result in increased synaptic connections of sensory neurons with their projection neuron (PN) partners, which are conserved in number between species. Surprisingly, having more OSNs does not lead to greater odour-evoked PN sensitivity or reliability. Rather, pathways with increased sensory pooling exhibit reduced PN adaptation, likely through weakened lateral inhibition. Our work reveals an unexpected functional impact of sensory neuron population expansions to explain ecologically-relevant, species-specific behaviour.
(© 2024. The Author(s).)
Databáze: MEDLINE
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