Clinical and nutritional correlates associated with weight changes in achalasia patients and the impact of laparoscopic Heller myotomy.

Autor: Aurino L; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy, Via Pansini 5, 80131, Naples, Italy. Electronic address: laura.aurino@unina.it., Pesce M; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy, Via Pansini 5, 80131, Naples, Italy. Electronic address: marcella.pesce@unina.it., Rurgo S; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy, Via Pansini 5, 80131, Naples, Italy. Electronic address: sararurgo91@gmail.com., Puoti MG; Department of Pediatric Gastroenterology and Hepatology, Santobono-Pausilipon Children's Hospital, Via Mario Fiore, 6, 80129, Naples, Italy. Electronic address: giovanna.puoti@hotmail.it., Polese B; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy, Via Pansini 5, 80131, Naples, Italy. Electronic address: barbara.polese@gmail.com., Capuano M; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy, Via Pansini 5, 80131, Naples, Italy. Electronic address: marianna.capuano@unina.it., Palomba G; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy, Via Pansini 5, 80131, Naples, Italy. Electronic address: giuseppepalomba3@virgilio.it., Aprea G; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy, Via Pansini 5, 80131, Naples, Italy. Electronic address: aprea@unina.it., Seguella L; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. Electronic address: luisa.seguella@uniroma1.it., Esposito G; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. Electronic address: giuseppe.esposito@uniroma1.it., Palenca I; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. Electronic address: irene.palenca@uniroma1.it., Efficie E; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy, Via Pansini 5, 80131, Naples, Italy. Electronic address: eleonora.efficie@hotmail.it., Sarnelli G; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Naples, Italy, Via Pansini 5, 80131, Naples, Italy. Electronic address: sarnelli@unina.it.
Jazyk: angličtina
Zdroj: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2024 Aug 14. Date of Electronic Publication: 2024 Aug 14.
DOI: 10.1016/j.dld.2024.07.027
Abstrakt: Background: Achalasia is characterized by symptoms of esophageal obstruction, preventing food consumption. However, weight loss is observed only in a subset of patients, and data from literature is conflicting.
Aims: Our study aimed at evaluating predictors of weight loss in achalasia patients and at verifying the impact of treatment on nutritional status.
Methods: 123 achalasia patients, eligible for laparoscopic Heller myotomy, were studied. Demographic, clinical and nutritional data (calorie intake and macronutrient composition) were recorded at baseline and one-year post-treatment. Significant weight loss/gain was considered for variation of 10 % of body weight at baseline and post-treatment, respectively.
Results: 57.7 % of patients reported weight loss at presentation. These subjects had shorter disease duration, worse symptoms, lower BMI and consumed fewer calories than patients without weight loss. Post-treatment, we observed a considerable improvement in Eckardt score and BMI values. Almost 50 % of the population reported significant weight gain, particularly in individuals with weight loss at baseline. Caloric intake also rose significantly, positively affecting BMI categories.
Conclusion: We showed that achalasia-induced weight loss is associated with symptoms' severity and disease duration. Conversely, over 50 % of treated patients were in the overweight/obese category, highlighting the need for individualized nutritional interventions in achalasia patients.
Competing Interests: Conflict of interest The Authors declare that there is no conflict of interest.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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