Medial Prefrontal Cortex Stimulation Reduces Retrieval-Induced Forgetting via Fronto-parietal Beta Desynchronization.

Autor:	Khan A; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB2 7EF, United Kingdom., Ti CHE; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China., Yuan K; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China., Crespo Garcia M; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB2 7EF, United Kingdom., Anderson MC; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB2 7EF, United Kingdom michael.anderson@mrc-cbu.cam.ac.uk kytong@cuhk.edu.hk., Tong RK; Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China michael.anderson@mrc-cbu.cam.ac.uk kytong@cuhk.edu.hk.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Sep 11; Vol. 44 (37). Date of Electronic Publication: 2024 Sep 11.
DOI:	10.1523/JNEUROSCI.0189-24.2024
Abstrakt:	The act of recalling memories can paradoxically lead to the forgetting of other associated memories, a phenomenon known as retrieval-induced forgetting (RIF). Inhibitory control mechanisms, primarily mediated by the prefrontal cortex, are thought to contribute to RIF. In this study, we examined whether stimulating the medial prefrontal cortex (mPFC) with transcranial direct current stimulation modulates RIF and investigated the associated electrophysiological correlates. In a randomized study, 50 participants (27 males and 23 females) received either real or sham stimulation before performing retrieval practice on target memories. After retrieval practice, a final memory test to assess RIF was administered. We found that stimulation selectively increased the retrieval accuracy of competing memories, thereby decreasing RIF, while the retrieval accuracy of target memories remained unchanged. The reduction in RIF was associated with a more pronounced beta desynchronization within the left dorsolateral prefrontal cortex (left-DLPFC), in an early time window (<500 ms) after cue onset during retrieval practice. This led to a stronger beta desynchronization within the parietal cortex in a later time window, an established marker for successful memory retrieval. Together, our results establish the causal involvement of the mPFC in actively suppressing competing memories and demonstrate that while forgetting arises as a consequence of retrieving specific memories, these two processes are functionally independent. Our findings suggest that stimulation potentially disrupted inhibitory control processes, as evidenced by reduced RIF and stronger beta desynchronization in fronto-parietal brain regions during memory retrieval, although further research is needed to elucidate the specific mechanisms underlying this effect. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 Khan et al.)
Databáze:	MEDLINE
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