Multiple factors influence telomere length and DNA damage in individuals environmentally exposed to a coal-burning power plant.

Autor: Souza MR; Laboratory of Genetic Toxicology, Lutheran University of Brazil (ULBRA) and LaSalle University (UniLaSalle), Avenida Farroupilha, 8001 Bairro São José, Canoas, RS CEP 92425-900, Brazil. Electronic address: melissa.eh@hotmail.com., Garcia ALH; Laboratory of Genetic Toxicology, Lutheran University of Brazil (ULBRA) and LaSalle University (UniLaSalle), Avenida Farroupilha, 8001 Bairro São José, Canoas, RS CEP 92425-900, Brazil., Dalberto D; Laboratory of Genetic Toxicology, Lutheran University of Brazil (ULBRA) and LaSalle University (UniLaSalle), Avenida Farroupilha, 8001 Bairro São José, Canoas, RS CEP 92425-900, Brazil., Picinini J; Laboratory of Genetic Toxicology, Lutheran University of Brazil (ULBRA) and LaSalle University (UniLaSalle), Avenida Farroupilha, 8001 Bairro São José, Canoas, RS CEP 92425-900, Brazil., Touguinha LBA; Laboratory of Oxidative Stress and Antioxidants, Institute of Biotechnology, University of Caxias do Sul (UCS), Caxias do Sul, RS, Brazil., Salvador M; Laboratory of Oxidative Stress and Antioxidants, Institute of Biotechnology, University of Caxias do Sul (UCS), Caxias do Sul, RS, Brazil., da Silva J; Laboratory of Genetic Toxicology, Lutheran University of Brazil (ULBRA) and LaSalle University (UniLaSalle), Avenida Farroupilha, 8001 Bairro São José, Canoas, RS CEP 92425-900, Brazil. Electronic address: juliana.silva@unilasalle.edu.br.
Jazyk: angličtina
Zdroj: Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2024 Aug-Sep; Vol. 898, pp. 503793. Date of Electronic Publication: 2024 Jul 05.
DOI: 10.1016/j.mrgentox.2024.503793
Abstrakt: Coal is a mixture of several chemicals, many of which have mutagenic and carcinogenic effects and are a key contributor to the global burden of mortality and disease. Previous studies suggest that coal is related to telomeric shortening in individuals occupationally exposed, however little is known about the effects of mining and burning coal on the telomeres of individuals living nearby. Therefore, the primary objective of this investigation was to assess the impact of proximity to coal power plants and coal mines on the genomic instability of individuals environmentally exposed, while also exploring potential associations with individual characteristics, oxidative stress, inflammatory responses, and the presence of inorganic elements. This study involved 80 men participants from three cities around a thermoelectric power plant and one city unexposed to coal and byproducts. DNA was extracted from peripheral blood samples obtained from each participant, and the telomeres length (TL) was assessed using quantitative real-time polymerase chain reaction (qPCR) methodology. No significant difference was observed between exposed individuals (6227 ± 2884 bp) when compared to the unexposed group (5638 ± 2452 bp). Nevertheless, TL decrease was associated with age and risk for cardiovascular disease; and longer TL was found to be linked with increased concentrations of silicon and phosphorus in blood samples. No correlations were observed between TL with comet assay (visual score), micronucleus test, oxidative stress, and inflammatory results. Additional research is required to ascertain the potential correlation between these changes and the onset of diseases and premature mortality.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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