Toxicity reference values (TRVs) for force health protection: Gap identification and TRV prediction.

Autor: Sweeney LM; UES, Inc., 4401 Dayton Xenia Road, Dayton, OH, 45432, USA. Electronic address: lisa.sweeney.3.ctr@us.af.mil., Sterner TR; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 2728 Q Street, Building 837, Wright-Patterson Air Force Base, OH, 45433, USA.
Jazyk: angličtina
Zdroj: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2024 Sep; Vol. 152, pp. 105685. Date of Electronic Publication: 2024 Aug 13.
DOI: 10.1016/j.yrtph.2024.105685
Abstrakt: The mission of the Force Health Protection (FHP) program of the U.S. Air Force (USAF), sustaining the readiness of warfighters, relies on determinations of acceptable levels of exposure to a wide array of substances that USAF personnel may encounter. In many cases, exposure details are limited or authoritative toxicity reference values (TRVs) are unavailable. To address some of the TRV gaps, we are integrating several approaches to generate health protective exposure guidelines. Descriptions are provided for identification of chemicals of interest for USAF FHP (467 to date), synthesis of multiple TRVs to derive Operational Exposure Limits (OpELs), and strategies for identifying and developing candidate values for provisional OpELs when authoritative TRVs are lacking. Rodent bioassay-derived long-term Derived No Effect Levels (DNELs) for workers were available only for a minority of the substances with occupational TRV gaps (19 of 84). Additional occupational TRV estimation approaches were found to be straightforward to implement: Tier 1 Occupational Exposure Bands, cheminformatics approaches (multiple linear regression and novel nearest-neighbor approaches), and empirical adjustment of short term TRVs. Risk assessors working in similar contexts may benefit from application of the resources referenced and developed in this work.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Lisa M. Sweeney reports financial support was provided by Air Force Research Laboratory. Teresa R. Sterner reports financial support was provided by Air Force Research Laboratory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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