Annonaceae acetogenins: A potential treatment for gynecological and breast cancer.

Autor: Bravo-Alfaro DA; Tecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing, Epigmenio González 500 Fracc. San Pablo, Querétaro, Qro 76130, Mexico., Montalvo-González E; Laboratorio Integral de Investigación en Alimentos, Tecnológico Nacional de México-Instituto Tecnológico de Tepic. Av. Tecnológico 2595 Fracc. Lagos del Country, Tepic, Nayarit 63175, Mexico., Zapien-Macias JM; Horticultural Sciences Department, University of Florida, Institute of Food and Agricultural Sciences, Gainesville, FL 32611, United States of America., Sampieri-Moran JM; Unidad de Investigación y Desarrollo de Alimentos, Tecnológico Nacional de México/Instituto Tecnológico de Veracruz, M.A. de Quevedo 2779, Col. Formando Hogar, Veracruz, Ver 91897, Mexico., García HS; Unidad de Investigación y Desarrollo de Alimentos, Tecnológico Nacional de México/Instituto Tecnológico de Veracruz, M.A. de Quevedo 2779, Col. Formando Hogar, Veracruz, Ver 91897, Mexico. Electronic address: hugo.gg@veracruz.tecnm.mx., Luna-Bárcenas G; Tecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing, Epigmenio González 500 Fracc. San Pablo, Querétaro, Qro 76130, Mexico. Electronic address: gabriel.luna@tec.mx.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Oct; Vol. 178, pp. 106187. Date of Electronic Publication: 2024 Aug 13.
DOI: 10.1016/j.fitote.2024.106187
Abstrakt: Breast and gynecological cancers are major health concerns due to their increasing incidence rates, and in some cases, their low survival probability. In recent years, multiple compounds of natural origin have been analyzed as alternative treatments for this disease. For instance, Acetogenins are plant secondary metabolites from the Annonaceae family, and its potential anticancer activity has been reported against a wide range of cancer cells both in vitro and in vivo. Several studies have demonstrated promising results of Acetogenins' antitumor capacity, given their selective activity of cellular inhibition at low concentrations. This review outlines the origin, structure, and antineoplastic activities in vitro and in vivo of Acetogenins from Annonaceae against breast cancer and gynecological cancers reported to date. Here, we also provide a systematic summary of the activity and possible mechanisms of action of Acetogenins against these types of cancer and provide references for developing future therapies based on Acetogenins and nanotechnologies.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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