The quality-adjusted life-years loss due to serogroup B invasive meningococcal disease in Spain.

Autor: García A; GSK, Tres Cantos, Spain. Electronic address: andrea.x.garcia@gsk.com., Vallejo-Aparicio LA; GSK, Tres Cantos, Spain., Begum N; Freelance C/O GSK, Wavre, Belgium., Nikitas G; GSK, Wavre. Belgium., González-Inchausti C; GSK, Tres Cantos, Spain., de Gomensoro E; GSK, Tres Cantos, Spain.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Sep 17; Vol. 42 (22), pp. 126155. Date of Electronic Publication: 2024 Aug 14.
DOI: 10.1016/j.vaccine.2024.126155
Abstrakt: Introduction: Despite its impact on a patient's life, there is a paucity of evidence on the humanistic burden of invasive meningococcal disease (IMD) due to serogroup B (MenB) in Spain. This study estimates the total quality-adjusted life-year (QALY) loss due to MenB-IMD in Spain from a societal perspective.
Materials and Methods: A previously published incidence-based Excel tool adapted to the Spanish setting was used to estimate total QALY losses over a patient's lifetime horizon, including direct and indirect impact on patients and families/caregivers, respectively. A 3% discount rate was applied, and a deterministic and probabilistic sensitivity analyses were performed to evaluate uncertainty and assumptions used for the base case.
Results: The total discounted QALY loss for a hypothetical cohort of 142 cases of MenB-IMD was 572.44 QALYs (4.03/case). Direct loss (attributable to patients) represented 81.2% of the total loss (464.54 QALYs; 3.27/case) and indirect loss (caused to relatives/ caregivers) represented 18.8% (108.90 QALYs; 0.76/case). Sequelae had the highest impact on QALY loss for both patients (60.5%) and relatives/caregivers (84.6%). Children <5 years of age (YOA) accounted for 47.8% of the total QALY loss. Mortality accounted for 17.62 QALY loss per death. The discount rate parameter showed the highest influence on results and the probabilistic sensitivity analysis revealed a 98.0% probability of total QALY loss achieving the point estimate.
Conclusions: The results emphasize that the humanistic burden associated with a MenB case is mainly driven by its sequelae, impacting the patients and their relatives/caregivers.
Competing Interests: Declaration of competing interest AG, LAV-A, GN and CGI are employees of GSK. LAV-A, GN and CGI hold financial equities in GSK. EdG was a GSK employee at the time of the study was performed. NB is a freelance consultant for GSK. All authors declare no other financial and non-financial relationships and activities.
(Copyright © 2024 GSK. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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