Phenomenological patterns and aetiological spectrum in patients visiting a tertiary care Movement disorders service in India: An observational study.

Autor: Kumar N; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India; Dept. of Neurology, All India Institute of Medical Sciences, Bibinagar, Metropolitan Region, Hyderabad, India. Electronic address: drnirajkumarsingh@gmail.com., Desai I; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India., Kumar M; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India., Singh J; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India., Tiwari A; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India., Dhar N; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India., Madhaw G; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India., Manchanda R; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India., Jatale V; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India., Radhakrishnan DM; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India; Dept. of Neurology, All India Institute of Medical Sciences, New Delhi, India., Warrier AR; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India; Dept. of Neurology & Neuro-intervention, Baby Memorial Hospital, Calicut, Kerala, India., Shree R; Dept. of Neurology, All India Institute of Medical Sciences, Rishikesh, India; Dept. of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Kumari S; Dept. of Ophthalmology, All India Institute of Medical Sciences, Rishikesh, India; Dept. of Ophthalmology, MediCiti Institute of Medical Sciences, Hyderabad, India.
Jazyk: angličtina
Zdroj: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2024 Oct; Vol. 245, pp. 108492. Date of Electronic Publication: 2024 Aug 03.
DOI: 10.1016/j.clineuro.2024.108492
Abstrakt: Objective: Although previous studies have described phenomenological diagnoses, they lacked description of aetiological spectrum in patients visiting movement disorders (MD) service. Herein, we classify the MD phenomenology and describe aetiology wise distribution of each phenomenology in patients visiting a tertiary care movement disorders service.
Methods: Collected information included demographic profile (age of onset, age at presentation, gender, duration of illness before presentation), predominant MD phenomenology [such as parkinsonism, dystonia, ataxia, tremor, chorea, ballism, myoclonus, tics, stereotypy, restless legs syndrome (RLS) and others], diagnostic evaluations and detected aetiology.
Results: This observational study included 1140 MD patients over a span of 5 years. The median (IQR) age of onset was 49 (35-60) years and age at presentation was 54 (40-65) years, with median duration of illness being 36 (18-72) months. Nearly two-third of patients were males (M:F=731:409). Parkinsonism (n=494, 43.3 %) was the most common MD phenomenology observed, followed by dystonia (n=219, 19.2 %), ataxia (n=125, 11 %), tremor (n=118, 10.4 %), myoclonus (n=73, 6.4 %), chorea (n=40, 3.5 %), spasticity (n=22, 1.9 %), tics (n=8, 0.7 %), and RLS (n=8, 0.7 %). Thirty-three (2.9 %) patients were grouped under miscellaneous MDs. Overall, neurodegenerative disorders (57.4 %) were the most common cause of MDs. Parkinson's disease, genetic dystonia, essential tremor, genetic ataxias, hemifacial spasm, and Huntington's disease were the most common aetiologies for parkinsonism, dystonia, tremor, ataxia, myoclonus, and chorea, respectively.
Conclusion: Parkinsonism was the most common phenomenology observed in MD patients, and was followed by dystonia, ataxia and tremor. Neurodegenerative disorders were the most common aetiology detected.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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