Progress in Noninvasive Low-Intensity Focused Ultrasound Neuromodulation.

Autor:	Feng J; Division of Vascular Neurology, Department of Neurology (J.F., Z.L.), Beijing Tiantan Hospital, Capital Medical University, China., Li Z; Division of Vascular Neurology, Department of Neurology (J.F., Z.L.), Beijing Tiantan Hospital, Capital Medical University, China.; China National Clinical Research Center for Neurological Diseases (Z.L.), Beijing Tiantan Hospital, Capital Medical University, China.; Chinese Institute for Brain Research, Beijing, China (Z.L.).
Jazyk:	angličtina
Zdroj:	Stroke [Stroke] 2024 Oct; Vol. 55 (10), pp. 2547-2557. Date of Electronic Publication: 2024 Aug 15.
DOI:	10.1161/STROKEAHA.124.046679
Abstrakt:	Low-intensity focused ultrasound represents groundbreaking medical advancements, characterized by its noninvasive feature, safety, precision, and broad neuromodulatory capabilities. This technology operates through mechanisms, for example, acoustic radiation force, cavitation, and thermal effects. Notably, with the evolution of medical technology, ultrasound neuromodulation has been gradually applied in treating central nervous system diseases, especially stroke. Furthermore, burgeoning research areas such as sonogenetics and nanotechnology show promising potential. Despite the benefit of low-intensity focused ultrasound the precise biophysical mechanism of ultrasound neuromodulation still need further exploration. This review discusses the recent and ongoing developments of low-intensity focused ultrasound for neurological regulation, covering the underlying rationale to current utility and the challenges that impede its further development and broader adoption of this promising alternative to noninvasive therapy. Competing Interests: None.
Databáze:	MEDLINE
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