A comprehensive review on potential role of selenium, selenoproteins and selenium nanoparticles in male fertility.

Autor:	Yuan S; College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, China., Zhang Y; Advanced Medical Research Institute, Shandong University, Jinan, Shandong, 250014, China., Dong PY; College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, China., Chen Yan YM; College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, China., Liu J; Analytical & Testing Center of Qingdao Agricultural University, Qingdao, 266100, China., Zhang BQ; Qingdao Restore Biotechnology Co., Ltd., Qingdao, 266111, China.; Key Laboratory of Cancer and Immune Cells of Qingdao, Qingdao, 266111, China., Chen MM; Qingdao Restore Biotechnology Co., Ltd., Qingdao, 266111, China.; Key Laboratory of Cancer and Immune Cells of Qingdao, Qingdao, 266111, China., Zhang SE; Animal Husbandry General Station of Shandong Province, Jinan, 250010, China., Zhang XF; College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, China.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 Jul 19; Vol. 10 (15), pp. e34975. Date of Electronic Publication: 2024 Jul 19 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e34975
Abstrakt:	Selenium (Se), a component of selenoproteins and selenocompounds in the human body, is crucial for the development of male reproductive organs, DNA synthesis, thyroid hormone, metabolism, and defence against infections and oxidative damage. In the testis, it must exceed a desirable level since either a shortage or an overabundance causes aberrant growth. The antioxidant properties of selenium are essential for preserving human reproductive health. Selenoproteins, which have important structural and enzymatic properties, control the biological activities of Se primarily. These proteins specifically have a role in metabolism and a variety of cellular processes, such as the control of selenium transport, thyroid hormone metabolism, immunity, and redox balance. Selenium nanoparticles (SeNPs) are less hazardous than selenium-based inorganic and organic materials. Upon being functionalized with active targeting ligands, they are both biocompatible and capable of efficiently delivering combinations of payloads to particular cells. In this review, we discuss briefly the chemistry, structure and functions of selenium and milestones of selenium and selenoproteins. Next we discuss the various factors influences male infertility, biological functions of selenium and selenoproteins, and role of selenium and selenoproteins in spermatogenesis and male fertility. Furthermore, we discuss the molecular mechanism of selenium transport and protective effects of selenium on oxidative stress, apoptosis and inflammation. We also highlight critical contribution of selenium nanoparticles on male fertility and spermatogenesis. Finally ends with conclusion and future perspectives. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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