Emerging Landscape of In Vitro Models for Assessing Rheumatoid Arthritis Management.

Autor:	Mishra AP; Department of Pharmacology, University of Free State, Bloemfontein 9301, South Africa.; Department of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand., Kumar R; Faculty of Pharmaceutical Sciences, Kerala University of Health Sciences, Kerala 680596, India., Harilal S; Faculty of Pharmaceutical Sciences, Kerala University of Health Sciences, Kerala 680596, India., Nigam M; Department of Biochemistry, Hemvati Nandan Bahuguna Garhwal University, Srinagar Garhwal, Uttarakhand 246174, India., Datta D; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India., Singh S; Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.; Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Jazyk:	angličtina
Zdroj:	ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2024 Jul 18; Vol. 7 (8), pp. 2280-2305. Date of Electronic Publication: 2024 Jul 18 (Print Publication: 2024).
DOI:	10.1021/acsptsci.4c00260
Abstrakt:	Rheumatoid arthritis (RA) is a complex condition that is influenced by various causes, including immunological, genetic, and environmental factors. Several studies using animal models have documented immune system dysfunction and described the clinical characteristics of the disease. These studies have provided valuable insights into the pathogenesis of inflammatory arthritis and the identification of new targets for treatment. Nevertheless, none of these animal models successfully replicated all the characteristics of RA. Additionally, numerous experimental medications, which were developed based on our enhanced comprehension of the immune system's function in RA, have shown potential in animal research but ultimately proved ineffective during different stages of clinical trials. There have been several novel therapy alternatives, which do not achieve a consistently outstanding therapeutic outcome in all patients. This underscores the importance of employing the progress in in vitro models, particularly 3D models like tissue explants, and diverse multicomponent approaches such as coculture strategies, synovial membrane, articular cartilage, and subchondral bone models that accurately replicate the structural characteristics of RA pathophysiology. These methods are crucial for the advancement of potential therapeutic strategies. This review discusses the latest advancements in in vitro models and their potential to greatly impact research on managing RA. Competing Interests: The authors declare no competing financial interest. (© 2024 American Chemical Society.)
Databáze:	MEDLINE
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