Radiation-induced skin injury in the head and neck region: pathogenesis, clinics, prevention, treatment considerations and proposal for management algorithm.

Autor:	Pazdrowski J; Department of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland.; Department of Head and Neck Surgery, Greater Poland Cancer Centre, Poznan, Poland., Gornowicz-Porowska J; Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medical Sciences, Poznan, Poland., Kaźmierska J; Department of Radiotherapy, Poznan University of Medical Sciences, Poznan, Poland.; Radiotherapy and Oncology, Greater Poland Cancer Centre, Poznan, Poland., Krajka-Kuźniak V; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Poznan, Poland., Polanska A; Department of Dermatology and Venereology Poznan University of Medical Sciences, Poznan, Poland., Masternak M; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States., Szewczyk M; Department of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland.; Department of Head and Neck Surgery, Greater Poland Cancer Centre, Poznan, Poland., Golusiński W; Department of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland.; Department of Head and Neck Surgery, Greater Poland Cancer Centre, Poznan, Poland., Danczak-Pazdrowska A; Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
Jazyk:	angličtina
Zdroj:	Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology [Rep Pract Oncol Radiother] 2024 Jul 22; Vol. 29 (3), pp. 373-390. Date of Electronic Publication: 2024 Jul 22 (Print Publication: 2024).
DOI:	10.5603/rpor.100775
Abstrakt:	Worldwide increase of head and neck cancers ranks these malignancies among top causes of cancer in human population. Radiation induced skin injury (RISI) is one of the major side effects of radiotherapy (RT). Skin of the neck is exposed to radiation due to necessity of therapeutic or prophylactic (elective) irradiation of neck lymph nodes and target organs, including the larynx and hypopharynx. The location of the neck exposes these regions of the skin to various additional exposomes such as ultraviolet radiation (UVR), pollution and cigarette smoke. There are many controversies or inconsistencies regarding RISI, from molecular aspects and therapy to terminology. There is lack of high-quality and large-sample studies in both forms of RISI: acute (aRISI) and chronic (cRISI). Finally, no gold standards in the management of aRISI and cRISI have been established yet. In this article, the authors discuss the pathogenesis, clinical picture, prevention and clinical interventions and present a proposed treatment algorithm. (© 2024 Greater Poland Cancer Centre.)
Databáze:	MEDLINE
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