Current Auditory Hallucinations Are Not Associated With Specific White Matter Diffusion Alterations in Schizophrenia.

Autor:	Nerland S; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Slapø NB; Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Barth C; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Mørch-Johnsen L; Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychiatry, Østfold Hospital, Grålum, Norway.; Department of Clinical Research, Østfold Hospital, Grålum, Norway., Jørgensen KN; Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Beck D; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Wortinger LA; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Westlye LT; Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Jönsson EG; Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden., Andreassen OA; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Maximov II; Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway., Geier OM; Department of Computational Radiology and Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.; Center for Lifespan Changes in Brain and Cognition (LCBC), Department of Psychology, University of Oslo, Oslo, Norway., Agartz I; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
Jazyk:	angličtina
Zdroj:	Schizophrenia bulletin open [Schizophr Bull Open] 2024 Apr 17; Vol. 5 (1), pp. sgae008. Date of Electronic Publication: 2024 Apr 17 (Print Publication: 2024).
DOI:	10.1093/schizbullopen/sgae008
Abstrakt:	Background and Hypothesis: Studies have linked auditory hallucinations (AH) in schizophrenia spectrum disorders (SCZ) to altered cerebral white matter microstructure within the language and auditory processing circuitry (LAPC). However, the specificity to the LAPC remains unclear. Here, we investigated the relationship between AH and DTI among patients with SCZ using diffusion tensor imaging (DTI). Study Design: We included patients with SCZ with (AH+; n  = 59) and without (AH-; n  = 81) current AH, and 140 age- and sex-matched controls. Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were extracted from 39 fiber tracts. We used principal component analysis (PCA) to identify general factors of variation across fiber tracts and DTI metrics. Regression models adjusted for sex, age, and age 2 were used to compare tract-wise DTI metrics and PCA factors between AH+, AH-, and healthy controls and to assess associations with clinical characteristics. Study Results: Widespread differences relative to controls were observed for MD and RD in patients without current AH. Only limited differences in 2 fiber tracts were observed between AH+ and controls. Unimodal PCA factors based on MD, RD, and AD, as well as multimodal PCA factors, differed significantly relative to controls for AH-, but not AH+. We did not find any significant associations between PCA factors and clinical characteristics. Conclusions: Contrary to previous studies, DTI metrics differed mainly in patients without current AH compared to controls, indicating a widespread neuroanatomical distribution. This challenges the notion that altered DTI metrics within the LAPC is a specific feature underlying AH. (© The Author(s) 2024. Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center.)
Databáze:	MEDLINE
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