Cardiac doses with deep inspiration breath hold in breast cancer radiotherapy: direct comparison between WBI, PBI, and interstitial APBI.

Autor:	Sirak I; Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Králové, Czech Republic., Pohanková D; Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Králové, Czech Republic., Kašaová L; Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Králové, Czech Republic., Hodek M; Clinic of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.; 4 Department of Internal Medicine - Hematology, University Hospital Hradec Kralove, Charles University Faculty of Medicine in Hradec Králové, Hradec Kralove, Czech Republic., Motyčka P; Department of Surgery, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic., Asqar A; Department of Surgery, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic., Grepl J; Department of Radiotherapy and Oncology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.; Department of Radiobiology, University of Defence in Brno, Brno, Czech Republic., Paluska P; Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Králové, Czech Republic., Novotná V; Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Králové, Czech Republic., Vosmik M; Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Králové, Czech Republic., Petera J; Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Králové, Czech Republic.
Jazyk:	angličtina
Zdroj:	Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology [Rep Pract Oncol Radiother] 2024 Jun 06; Vol. 29 (2), pp. 155-163. Date of Electronic Publication: 2024 Jun 06 (Print Publication: 2024).
DOI:	10.5603/rpor.99907
Abstrakt:	Background: The optimal radiotherapy technique for cardiac sparing in left-sided early breast cancer (EBC) is not clear. In this context, the aim of our dosimetric study was to compare cardiac and lung doses according to the type of radiotherapy - whole breast irradiation (WBI), external partial breast irradiation (PBI), and multicatheter interstitial brachytherapy-accelerated partial breast irradiation (MIB-APBI). The dosimetric results with the WBI and PBI were calculated with and without DIBH. Materials and Methods: Dosimetric study of 23 patients treated with WBI, PBI, with and without DIBH, or MIB-APBI. The prescribed dose was 40 Gy in 15 fractions for WBI and PBI and 34 Gy in 10 fractions (bid) for MIB-APBI. Doses to the organs-at-risk (OAR) - heart, left anterior descending coronary artery (LAD), left ventricle (LV), and left lung - were recalculated to the equivalent dose in 2-Gy fractions (EQD2). Results: The addition of DIBH significantly reduced EQD2 doses to all OARs (except for the left lung maximal dose) in WBI and PBI. MHD values were 0.72 Gy for DIBH-WBI, 1.01 Gy for MIB-APBI and 0.24 Gy for DIBH-PBI. There were no significant differences in cardiac doses between WBI with DIBH and PBI without DIBH. DIBH-PBI resulted in significantly lower mean doses to all OARs (except for maximum lung dose) compared to MIB-APBI. Conclusions: These results show that the use of DIBH significantly reduces cardiac doses in patients with left EBC. Partial irradiation techniques (PBI, MIB-APBI) significantly reduced cardiac doses due to the smaller clinical target volume. The best results were obtained with DIBH-PBI. Competing Interests: Conflict of interests: Authors declare no conflict of interests. (© 2024 Greater Poland Cancer Centre.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu