Dysregulation of Porphyromonas gingivalis Agmatine Deiminase Expression in Alzheimer's Disease.

Autor:	Hamdi A; Laboratory of Microorganisms and Active Biomolecules (LR03ES03), Faculty of Sciences of Tunis, University of Tunis El Manar, Campus Universitaire 2092, Tunis, Tunisia., Baroudi S; Laboratory of Microorganisms and Active Biomolecules (LR03ES03), Faculty of Sciences of Tunis, University of Tunis El Manar, Campus Universitaire 2092, Tunis, Tunisia., Gharbi A; Neurology Department, Razi University Hospital, Manouba, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, La Rabta, Tunis, Tunisia.; Clinical Investigation Center (CIC), Razi University Hospital, Manouba, Tunisia., Babay W; Laboratory of Microorganisms and Active Biomolecules (LR03ES03), Faculty of Sciences of Tunis, University of Tunis El Manar, Campus Universitaire 2092, Tunis, Tunisia., Laaribi AB; Laboratory of Microorganisms and Active Biomolecules (LR03ES03), Faculty of Sciences of Tunis, University of Tunis El Manar, Campus Universitaire 2092, Tunis, Tunisia., Kacem I; Neurology Department, Razi University Hospital, Manouba, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, La Rabta, Tunis, Tunisia.; Clinical Investigation Center (CIC), Razi University Hospital, Manouba, Tunisia., Mrabet S; Neurology Department, Razi University Hospital, Manouba, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, La Rabta, Tunis, Tunisia.; Clinical Investigation Center (CIC), Razi University Hospital, Manouba, Tunisia., Zidi I; Laboratory of Microorganisms and Active Biomolecules (LR03ES03), Faculty of Sciences of Tunis, University of Tunis El Manar, Campus Universitaire 2092, Tunis, Tunisia., Klibi N; Laboratory of Microorganisms and Active Biomolecules (LR03ES03), Faculty of Sciences of Tunis, University of Tunis El Manar, Campus Universitaire 2092, Tunis, Tunisia., Gouider R; Neurology Department, Razi University Hospital, Manouba, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, La Rabta, Tunis, Tunisia.; Clinical Investigation Center (CIC), Razi University Hospital, Manouba, Tunisia., Ouzari HI; Laboratory of Microorganisms and Active Biomolecules (LR03ES03), Faculty of Sciences of Tunis, University of Tunis El Manar, Campus Universitaire 2092, Tunis, Tunisia.
Jazyk:	angličtina
Zdroj:	Current Alzheimer research [Curr Alzheimer Res] 2024; Vol. 21 (4), pp. 232-241.
DOI:	10.2174/0115672050327009240808103542
Abstrakt:	Background: Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, with a significant burden on global health. AD is characterized by a progressive cognitive decline and memory loss. Emerging research suggests a potential link between periodontitis, specifically the presence of oral bacteria such as Porphyromonas gingivalis ( P. gingivalis ), and AD progression. P. gingivalis produces an enzyme, Agmatine deiminase (AgD), which converts agmatine to N-carbamoyl putrescine (NCP), serving as a precursor to essential polyamines. Recent studies have confirmed the correlation between disruptions in polyamine metabolism and cognitive impairment. Objective: This study aims to investigate the dysregulation of P. gingivalis Agmatine deiminase ( PgAgD ) in the context of AD. Methods: Saliva samples were collected from a total of 54 individuals, including 27 AD patients and 27 healthy controls. The expression of the PgAgD gene was analyzed using quantitative Real-- Time PCR. Results: The results showed a significant decrease in PgAgD gene expression in the saliva samples of AD patients compared to healthy controls. This downregulation was found in AD patients with advanced stages of periodontitis. Additionally, a correlation was observed between the decrease in PgAgD expression and the 30-item Mini-Mental State Examination (MMSE) score. Conclusion: These findings suggest that measuring PgAgD expression in saliva could be a noninvasive tool for monitoring AD progression and aid in the early diagnosis of patients with periodontitis. Further research is needed to validate our results and explore the underlying mechanisms linking periodontitis, PgAgD expression, and AD pathophysiology. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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