Community use of oral antibiotics transiently reprofiles the intestinal microbiome in young Bangladeshi children.

Autor: Baldi A; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. Baldi.a@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. Baldi.a@wehi.edu.au., Braat S; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Centre for Epidemiology and Biostatistics, University of Melbourne School of Population and Global Health, Carlton, VIC, Australia.; Department of Infectious Diseases at the Peter Doherty Institute of Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia., Imrul Hasan M; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh., Bennett C; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Barrios M; Advanced Technology and Biology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Jones N; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Moir-Meyer G; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Abdul Azeez I; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Wilcox S; Advanced Technology and Biology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Saiful Alam Bhuiyan M; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh., Ataide R; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Infectious Diseases at the Peter Doherty Institute of Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia., Clucas D; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.; Diagnostic Haematology, The Royal Melbourne Hospital, Parkville, VIC, Australia., Harrison LC; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Arifeen SE; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh., Bowden R; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.; Advanced Technology and Biology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Biggs BA; Department of Infectious Diseases at the Peter Doherty Institute of Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.; Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC, Australia., Jex A; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.; Faculty of Science, University of Melbourne, Melbourne, VIC, Australia., Pasricha SR; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. Pasricha.s@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. Pasricha.s@wehi.edu.au.; Diagnostic Haematology, The Royal Melbourne Hospital, Parkville, VIC, Australia. Pasricha.s@wehi.edu.au.; Clinical Haematology at The Royal Melbourne Hospital and the Peter MacCallum Cancer Centre, Parkville, VIC, Australia. Pasricha.s@wehi.edu.au.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Aug 14; Vol. 15 (1), pp. 6980. Date of Electronic Publication: 2024 Aug 14.
DOI: 10.1038/s41467-024-51326-5
Abstrakt: Antibiotics may alter the gut microbiome, and this is one of the mechanisms by which antimicrobial resistance may be promoted. Suboptimal antimicrobial stewardship in Asia has been linked to antimicrobial resistance. We aim to examine the relationship between oral antibiotic use and composition and antimicrobial resistance in the gut microbiome in 1093 Bangladeshi infants. We leverage a trial of 8-month-old infants in rural Bangladesh: 61% of children were cumulatively exposed to antibiotics (most commonly cephalosporins and macrolides) over the 12-month study period, including 47% in the first 3 months of the study, usually for fever or respiratory infection. 16S rRNA amplicon sequencing in 11-month-old infants reveals that alpha diversity of the intestinal microbiome is reduced in children who received antibiotics within the previous 7 days; these samples also exhibit enrichment for Enterococcus and Escherichia/Shigella genera. No effect is seen in children who received antibiotics earlier. Using shotgun metagenomics, overall abundance of antimicrobial resistance genes declines over time. Enrichment for an Enterococcus-related antimicrobial resistance gene is observed in children receiving antibiotics within the previous 7 days, but not earlier. Presence of antimicrobial resistance genes is correlated to microbiome composition. In Bangladeshi children, community use of antibiotics transiently reprofiles the gut microbiome.
(© 2024. The Author(s).)
Databáze: MEDLINE
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