Oscillatory potential findings in patients with acute ischaemic central retinal vein occlusion.

Autor:	Qu Y; Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, China., Ran L; Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, China., Wang G; Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, China., Wang M; Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China.; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, China., Li S; Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, Fujian Province, People's Republic of China shiying_li@126.com.; Department of Ophthalmology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen, Fujian Province, People's Republic of China.
Jazyk:	angličtina
Zdroj:	BMJ open ophthalmology [BMJ Open Ophthalmol] 2024 Aug 13; Vol. 9 (1). Date of Electronic Publication: 2024 Aug 13.
DOI:	10.1136/bmjophth-2023-001582
Abstrakt:	Aims: To explore the sensitive components of full-field electroretinography (ERG) as indicators of retina function at the onset of acute ischaemic central retinal vein occlusion (CRVO). Methods: 11 patients (11 eyes) with ischaemic CRVO and 32 patients (32 eyes) with non-ischaemic CRVO who presented with first-episode unilateral CRVO within 1 month of symptom onset and with no previous intervention were examined by the International Society for Clinical Electrophysiology of Vision standard ERG. Results: A significant amplitude decline and peak time delay in light-adapted (LA) 3 ERG and LA 30 Hz flicker ERG (p<0.05 for all) was found in the ischaemic CRVO eyes, compared with the non-ischaemic CRVO eyes. The b/a amplitude ratio of dark-adapted (DA) 3 ERG, DA 10 ERG and LA 3 ERG was significantly different between the ischaemic and non-ischaemic groups (p<0.05 for all). Regarding oscillatory potentials (OPs), the amplitudes of OP1, OP2 and OP3 as well as the sum of DA 3 OP1-4 amplitudes (∑OPs) showed significant changes (p<0.01 for all) between two groups. No peak time delay of OPs was found between the ischaemic and non-ischaemic CRVO eyes. Conclusion: The amplitude of DA 0.01 ERG, components of LA 3 ERG and LA 30 Hz flicker ERG, and the b/a amplitude ratio could be among the most sensitive indicators in patients with acute ischaemic CRVO. The amplitudes of OP1, OP2, OP3 and ∑OPs in the CRVO eyes were reduced to 40% of the control values, showing that this quantitative method is reliable for detecting ischaemic retinal diseases, even in early stage. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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