Effects of the Paris System on the Unsatisfactory Category in a Cytohistologic Correlation Study of Patients With Urothelial Carcinoma.

Autor:	Coelho KMPA; From the Research Department, Centro de Diagnósticos Anátomo-Patológicos (CEDAP), Joinville, Brazil (Coelho, Fronza Jr, de Carvalho, Tagliari, Stall, da Silveira, de França).; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology (INCT BioOncoPed), Porto Alegre, Brazil (Coelho, Fronza Jr)., Fronza H Jr; From the Research Department, Centro de Diagnósticos Anátomo-Patológicos (CEDAP), Joinville, Brazil (Coelho, Fronza Jr, de Carvalho, Tagliari, Stall, da Silveira, de França).; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology (INCT BioOncoPed), Porto Alegre, Brazil (Coelho, Fronza Jr)., Carvalho P; From the Research Department, Centro de Diagnósticos Anátomo-Patológicos (CEDAP), Joinville, Brazil (Coelho, Fronza Jr, de Carvalho, Tagliari, Stall, da Silveira, de França).; the Diagnostic Department, BML Patologia, Blumenau, Brazil (de Carvalho)., Tagliari GB; From the Research Department, Centro de Diagnósticos Anátomo-Patológicos (CEDAP), Joinville, Brazil (Coelho, Fronza Jr, de Carvalho, Tagliari, Stall, da Silveira, de França).; the Diagnostic Department, Instituto de Patologia de Joaçaba, Joaçaba, Brazil (Tagliari)., Tavares LCC; From the Cytopathology Department, Centro de Diagnósticos Anátomo-Patológicos (CEDAP), Joinville, Brazil (de Tavares)., Stall J; From the Research Department, Centro de Diagnósticos Anátomo-Patológicos (CEDAP), Joinville, Brazil (Coelho, Fronza Jr, de Carvalho, Tagliari, Stall, da Silveira, de França).; Residency Program, Hospital Municipal São José, Joinville, Brazil (Stall, da Silveira)., Silveira HGD; From the Research Department, Centro de Diagnósticos Anátomo-Patológicos (CEDAP), Joinville, Brazil (Coelho, Fronza Jr, de Carvalho, Tagliari, Stall, da Silveira, de França).; Residency Program, Hospital Municipal São José, Joinville, Brazil (Stall, da Silveira)., França PHC; From the Research Department, Centro de Diagnósticos Anátomo-Patológicos (CEDAP), Joinville, Brazil (Coelho, Fronza Jr, de Carvalho, Tagliari, Stall, da Silveira, de França).; Postgraduate Program in Health and Environment, Universidade da Região de Joinville (Univille), Joinville, Brazil (de França).
Jazyk:	angličtina
Zdroj:	Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2024 Aug 15. Date of Electronic Publication: 2024 Aug 15.
DOI:	10.5858/arpa.2023-0506-OA
Abstrakt:	Context.—: The main objectives of the Paris System are to detect high-grade urothelial carcinoma, to standardize morphologic criteria and the cytopathologic report, to reduce the prevalence of the atypia category, and to improve the malignancy risk stratification. Objective.—: To compare the results and sensitivity of cytologic classification before and after reclassification by the Paris System. Design.—: Urinary cytology samples from patients with a histologic diagnosis of urothelial carcinoma were reclassified on the basis of the Paris System categories. The diagnoses before reclassification were divided into 5 categories (A, B, C, D, E) and compared with the Paris System (I, II, III, IV, V). Sensitivity was calculated considering cytohistologic agreement in relation to high-grade urothelial carcinoma. Results.—: A total of 111 urinary cytology samples from patients were analyzed, corresponding to 40 histologic samples; of these, 12 (30%) were high grade and the remaining were low grade. Comparison of the correlated categories showed an increase from 3 (3 of 111; 2.7%) (A) to 31 (31 of 111; 27.9%) (I) in unsatisfactory cases and a decrease from 67 (67 of 111; 60,0%) to 30 (30 of 111; 27.0%) in negative cases, while the atypia category remained unchanged (15 cases [15 of 111; 13.5%]) (C and III). Suspicious cases increased from 5 (5 of 111; 4.5%) (D) to 14 (14 of 111; 12.6%) (IV) and cases of urothelial carcinoma were unchanged (21 cases [21 of 111; 18.9%]) (E and V). Sensitivity was 69% for the previous classification and 90% for the Paris System. Conclusions.—: The Paris System improved the sensitivity of urinary cytology and the standardization of the unsatisfactory criteria, with an increase of cases in this category and a decrease of cases previously classified as negative among patients with a subsequent histologic diagnosis of urothelial carcinoma. (© 2024 College of American Pathologists.)
Databáze:	MEDLINE
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