Alpha-cyclodextrin increases glucagon-like peptide-1 secretion in multiple models and improves metabolic status in mice.

Autor: Smits MM; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: mm.smits1@amsterdamumc.nl., von Voss L; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Drzazga AK; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Lodz, Poland. Electronic address: anna.drzazga@sund.ku.dk., Beaman EE; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: emily.beaman@sund.ku.dk., Brethvad AO; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: aob@sund.ku.dk., Holst JJ; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. Electronic address: jjholst@sund.ku.dk., Rosenkilde MM; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: rosenkilde@sund.ku.dk.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2024 Dec 01; Vol. 460 (Pt 3), pp. 140759. Date of Electronic Publication: 2024 Aug 05.
DOI: 10.1016/j.foodchem.2024.140759
Abstrakt: Alpha-cyclodextrin (α-CD) is a non-absorbable and soluble fiber that causes weight loss. We studied whether this is due to an effect on GLP-1 secretion. In GLUTag cells, α-CD increased GLP-1 secretion up to 170% via adenylyl cyclase, phospholipase C, and L-type calcium channels dependent processes. In rat isolated colon perfusions, luminal α-CD increased GLP-1 secretion with 20%. In lean mice, once daily α-CD versus saline caused weight loss and lowered the peak in glucose after an oral glucose tolerance test (OGTT). In obese mice, α-CD added to high-fat diet caused weight loss similar to the control group (receiving cellulose). However, compared to cellulose, the α-CD group ate less. During an OGTT, no differences were observed in glucose, insulin and GLP-1. Thus, α-CD increases GLP-1 secretion in a dose-dependent manner and could be a safe and easy addition to food products to help reduce body weight.
Competing Interests: Declaration of competing interest MMS, LV, AKD, EEB and AOB have nothing to disclose. MMR and JJH are cofounders and minority shareholders in Antag Therapeutics. JJH: Advisory boards: Novo Nordisk; Lecture fees: Novo Nordisk; Merck. The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mark Smits reports financial support was provided by Lundbeck Foundation. Jens Juul Holst reports a relationship with Novo Nordisk that includes: consulting or advisory and speaking and lecture fees. Jens Juul Holst reports a relationship with Merck & Co Inc. that includes: speaking and lecture fees. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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