Role of gut microbial-derived metabolites and other select agents on adipocyte browning.

Autor: Nayak A; School of Biological Sciences, National Institute of Science Education and Research (NISER), Jatni, 752050, India; Homi Bhabha National Institute, Training School Complex, Mumbai, 400094, India; Centre for Interdisciplinary Science (CIS), National Institute of Science Education and Research (NISER), Jatni, 752050, India., Panda SS; School of Biological Sciences, National Institute of Science Education and Research (NISER), Jatni, 752050, India; Homi Bhabha National Institute, Training School Complex, Mumbai, 400094, India; Centre for Interdisciplinary Science (CIS), National Institute of Science Education and Research (NISER), Jatni, 752050, India., Dwivedi I; School of Biological Sciences, National Institute of Science Education and Research (NISER), Jatni, 752050, India; Homi Bhabha National Institute, Training School Complex, Mumbai, 400094, India; Centre for Interdisciplinary Science (CIS), National Institute of Science Education and Research (NISER), Jatni, 752050, India., Meena S; School of Biological Sciences, National Institute of Science Education and Research (NISER), Jatni, 752050, India; Homi Bhabha National Institute, Training School Complex, Mumbai, 400094, India; Centre for Interdisciplinary Science (CIS), National Institute of Science Education and Research (NISER), Jatni, 752050, India., Aich P; School of Biological Sciences, National Institute of Science Education and Research (NISER), Jatni, 752050, India; Homi Bhabha National Institute, Training School Complex, Mumbai, 400094, India; Centre for Interdisciplinary Science (CIS), National Institute of Science Education and Research (NISER), Jatni, 752050, India. Electronic address: palok.aich@niser.ac.in.
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Dec 10; Vol. 737, pp. 150518. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1016/j.bbrc.2024.150518
Abstrakt: Aims: Metabolic disease is a multifaceted condition characterized by the disruption of numerous metabolic parameters within the host. Its prevalence has surged significantly in recent years and it has become a prominent non-communicable disease worldwide. The effect of gut microbiota on various beige fat induction is well studied, while the mechanisms behind the link remain unclear. Given that gut microbiota-derived metabolites (meta-metabolites) secreted in the gut serve as a key mode of communication with their host through direct circulation or indirect host physiology modification, understanding the effect of meta-metabolites on adipose tissue is essential.
Methodology: In our previous in-vivo studies, we observed a correlation between gut microbiota and the formation of beige fat. In this study, we further aimed to validate this correlation by treating the adipocyte cell line (3T3-L1) with meta-metabolites collected from the cecum of mice exhibiting beige adipose tissue formation. Additionally, we treated the adipocyte cell line with known beige fat inducers (L-Rhamnose and Ginsenoside) to assess meta-metabolites' efficacy on beige fat formation.
Key Findings: Upon treatment with the meta-metabolites from the antibiotic-treated mice, we observed a significant increase in lipid metabolism and beige-specific gene expression. Analyzing the metabolites in these cells revealed that a set of metabolites potentially govern adipocytes, contributing to a metabolically active state. These effects were at par or even better than those of cells treated with L-Rhamnose or Ginsenoside.
Significance: This research sheds light on the intricate interplay between microbial metabolites and adipose tissue, offering valuable clues for understanding and potentially manipulating these processes for therapeutic purposes.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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