Remodeling p38 signaling in muscle controls locomotor activity via IL-15.

Autor:	Folgueira C; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Herrera-Melle L; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., López JA; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., Galvan-Alvarez V; Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria 35017, Spain.; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Canary Islands, Spain., Martin-Rincon M; Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria 35017, Spain.; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Canary Islands, Spain., Cuartero MI; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Unidad de Investigación Neurovascular, Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Madrid, Spain., García-Culebras A; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Departamento de Biología Celular, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Madrid, Spain., Dumesic PA; Dana Farber Cancer Institute (DFCI), Department of Cell Biology, Harvard University Medical School, Boston, MA, USA., Rodríguez E; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Leiva-Vega L; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., León M; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Porteiro B; Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain., Iglesias C; Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain., Torres JL; Complejo Asistencial de Zamora, Zamora, Spain., Hernández-Cosido L; Bariatric Surgery Unit, Department of General Surgery, University Hospital of Salamanca, Department of Surgery, University of Salamanca, Salamanca, Spain., Bonacasa C; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Marcos M; Department of Internal Medicine, University Hospital of Salamanca-IBSAL, Salamanca, Spain; Department of Medicine, University of Salamanca, Salamanca, Spain., Moro MÁ; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Vázquez J; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., Calbet JAL; Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria 35017, Spain.; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Canary Islands, Spain.; Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway., Spiegelman BM; Dana Farber Cancer Institute (DFCI), Department of Cell Biology, Harvard University Medical School, Boston, MA, USA., Mora A; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Sabio G; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2024 Aug 16; Vol. 10 (33), pp. eadn5993. Date of Electronic Publication: 2024 Aug 14.
DOI:	10.1126/sciadv.adn5993
Abstrakt:	Skeletal muscle has gained recognition as an endocrine organ releasing myokines upon contraction during physical exercise. These myokines exert both local and pleiotropic health benefits, underscoring the crucial role of muscle function in countering obesity and contributing to the overall positive effects of exercise on health. Here, we found that exercise activates muscle p38γ, increasing locomotor activity through the secretion of interleukin-15 (IL-15). IL-15 signals in the motor cortex, stimulating locomotor activity. This activation of muscle p38γ, leading to an increase locomotor activity, plays a crucial role in reducing the risk of diabetes and liver steatosis, unveiling a vital muscle-brain communication pathway with profound clinical implications. The correlation between p38γ activation in human muscle during acute exercise and increased blood IL-15 levels highlights the potential therapeutic relevance of this pathway in treating obesity and metabolic diseases. These findings provide valuable insights into the molecular basis of exercise-induced myokine responses promoting physical activity.
Databáze:	MEDLINE
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