Validation of the EQ-5D-Y-5L parent-proxy version among children with juvenile idiopathic arthritis.

Autor: Ohinmaa A; School of Public Health, University of Alberta, Edmonton, Canada., Wen J; School of Public Health, University of Alberta, Edmonton, Canada., Currie GR; Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada. currie@ucalgary.ca.; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. currie@ucalgary.ca.; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada. currie@ucalgary.ca., Benseler SM; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada., Swart JF; Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital / UMC Utrecht and University of Utrecht, Utrecht, The Netherlands., Vastert SJ; Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital / UMC Utrecht and University of Utrecht, Utrecht, The Netherlands., Yeung RSM; Department of Paediatrics, Immunology and Medical Science, The Hospital for Sick Children, University of Toronto, Toronto, Canada., Marshall DA; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.; McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Canada.; O'Brien Institute for Public Health, University of Calgary, Calgary, Canada.
Jazyk: angličtina
Zdroj: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2024 Oct; Vol. 33 (10), pp. 2677-2691. Date of Electronic Publication: 2024 Aug 14.
DOI: 10.1007/s11136-024-03682-4
Abstrakt: Objectives: Juvenile idiopathic arthritis (JIA) is the most common type of arthritis among children. It can cause joint pain and permanent physical damage, which affects mobility and daily activities. The EQ-5D-Y-3L self-report version has been validated in JIA, but the validity of EQ-5D-Y-5L remains unknown. We examined the psychometric properties of the EQ-5D-Y-5L parent-proxy version among children with JIA.
Methods: We used data from the Understanding Childhood Arthritis Network Canadian-Dutch collaboration study cohort, including patients with new-onset JIA, and those starting or stopping biologics. Clinical data and the parent-proxy version of the childhood health assessment questionnaire (CHAQ) and EQ-5D-Y-5L were collected. We evaluated the ceiling and floor effect; convergent and divergent validity using Spearman's rank correlation; known-group validity using one-way ANOVA (Analysis of Variance) and effect size; and informativity using Shannon's evenness index.
Results: 467 patient visits representing 407 patients were analyzed. The EQ-5D-Y-5L had no ceiling/floor effect. The EQ-5D-Y-5L showed good convergent (e.g., EQ-5D-Y-5L pain/discomfort dimension vs. CHAQ pain index (Spearman's r = 0.74, 95% confidence interval (C.I.): 0.69-0.79)), divergent (e.g., EQ-5D-Y-5L pain/discomfort dimension vs. CHAQ eating dimension (Spearman's r = 0.19, 95% C.I.: 0.09-0.29)) and known-group validity (e.g., mean EQ-5D-Y-5L level summary score for patients with inactive versus active disease status, 6.34 vs. 10.52 (p < 0.001, effect size = 1.20 (95% C.I.: 0.95-1.45)). Shannon's evenness index ranged from 0.52 to 0.88, suggesting most dimensions had relatively even distributions.
Conclusions: In this patient sample, EQ-5D-Y-5L parent-proxy version exhibited construct validity and informativity, suggesting the EQ-5D-Y-5L can be used to measure the quality of life of children with JIA.
(© 2024. The Author(s).)
Databáze: MEDLINE
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