Structurally Diverse Secondary Metabolites from a Deep-Sea Derived Cladosporium sp. SCSIO 41318and Their Biological Evaluation.

Autor: Zhang W; College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, 710069, China.; CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences, South China Sea Institute of Oceanology, Guangzhou, 510301, P. R., China., Yuan Y; College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, 710069, China.; CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences, South China Sea Institute of Oceanology, Guangzhou, 510301, P. R., China., Pang X; CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences, South China Sea Institute of Oceanology, Guangzhou, 510301, P. R., China., Liu Y; CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences, South China Sea Institute of Oceanology, Guangzhou, 510301, P. R., China., Zhang X; College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China., Liu Q; College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, 710069, China., Wang J; CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences, South China Sea Institute of Oceanology, Guangzhou, 510301, P. R., China.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Dec; Vol. 21 (12), pp. e202401751. Date of Electronic Publication: 2024 Oct 18.
DOI: 10.1002/cbdv.202401751
Abstrakt: Four new compounds, including one drimane sesquiterpene lactone (1), one isocoumarin (2), one coumarin (3), and a new natural product (4), as well as fourteen known compounds were obtained from a deep-sea derived Cladosporium sp. SCSIO 41318. The structures of the new compounds were determined using extensive NMR and HRESIMS spectroscopic analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction measurements. Biological assays showed that compounds (1, 6, 7, 9-12, 14, 15, 17, 18) exhibited varying degrees of antimicrobial activity against the tested human pathogenic bacteria and plant pathogenic fungi. Besides, penicitrinone A (11) and penicitrinol A (12) displayed weak antitumor activities against the 22Rv1 cell line.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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