Intralesional vitamin D3 versus intralesional triamcinolone acetonoid in patchy alopecia areata: a comparative clinical and dermoscopic study.
| Autor: | Ragaie MH; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Minya, Al, Egypt., Mohammed SE; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Minya, Al, Egypt., Shehata SS; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Minya, Al, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology [J Cosmet Laser Ther] 2024 Aug 14, pp. 1-5. Date of Electronic Publication: 2024 Aug 14. |
| DOI: | 10.1080/14764172.2024.2389275 |
| Abstrakt: | Background: Alopecia areata (AA) is a common autoimmune T -cell mediated non-scarring, form of hair loss. It affects people of all ages and sexes. Aim: To compare the efficacy of intralesional vitamin D3 injection versus that of intralesional triamcinolone acetonide in the treatment of patchy alopecia areata. Patients and Methods: This clinical study was carried on 40 adult patients with patchy alopecia areata, the patients were categorized into two groups. Group I involved 20 patients who received 1 ml of intralesional injection of vitamin D3 (cholecalciferol aqueous preparation 200 000 IU/2 ml) every 4 weeks for a maximum of three sessions. Group II involved 20 patients who received 1 ml of intralesional injection of triamcinolone acetonide 40 mg/mL every 4 weeks for a maximum of three sessions. Clinical and trichoscopic evaluations were done at the baseline, each session and for 3 months after the last session. Results: There was no statistically significant difference between the two studied groups regarding the degree of clinical improvement ( p = .8). A statistically significant reduction in AA specific trichoscopic signs was detected at the end of the sessions and after 3 months of follow-up in both groups, without any statistically significant difference between them. Also a statistically significant difference was found between both groups regarding the reported adverse effects with a significant better patient satisfaction encountered toward the intralesional vitamin D3 injection. Conclusion: Intralesional vitamin D3 is a promising effective, simple, safe, and inexpensive, therapeutic modality for patchy AA. |
| Databáze: | MEDLINE |
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