Intestinal Parasitic Infections May Be Overlooked Drivers of the Tuberculosis Pandemic.

Autor:	Steel LB; Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts., Narasimhan PB; Department of Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India., Chaudhari M; Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India., Dauphinais MR; Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts., Huang S; Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts., Beall K; Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts., Carwile ME; Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts., Cintron C; Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts., Du X; Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts., Heysell SK; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia., Lakshminarayanan S; Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India., Singh UB; Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India., Sinha P; Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.; Department of Internal Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.
Jazyk:	angličtina
Zdroj:	The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2024 Aug 13; Vol. 111 (4), pp. 719-723. Date of Electronic Publication: 2024 Aug 13 (Print Publication: 2024).
DOI:	10.4269/ajtmh.23-0637
Abstrakt:	The burden of tuberculosis (TB) is disproportionate in tropical and subtropical regions, where parasitic coinfections are common. Given the significant geographical overlap between TB and intestinal parasitic infections, it is important to consider the implications of intestinal parasitic infections for the TB pandemic. Intestinal parasitic infections have been theorized to increase vulnerability to TB by altering the inflammatory milieu, inducing undernutrition that blunts the immune response, and affecting drug pharmacokinetics. In this perspective, we provide a background of the epidemiological and immunological evidence that links parasitic infections to increased risk of TB progression and worse treatment outcomes. We also identify gaps in our knowledge and call for increased research on TB-parasitic coinfections to ensure action on a potentially widespread TB comorbidity.
Databáze:	MEDLINE
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