Elevated allostatic load is associated with poorer response to repetitive transcranial magnetic stimulation in treatment-resistant depression.

Autor: Longpré-Poirier C; Unité de Neuromodulation Psychiatrique (UNP), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du CHUM (CRCHUM), Université de Montréal, Montréal, Québec, Canada; Département de psychiatrie et d'addictologie, Université de Montréal, Montréal, Québec, Canada; Centre de recherche de l'Institut universitaire en santé mentale (CR-IUSMM), Université de Montréal, Montréal, Québec, Canada. Electronic address: christophe.longpre-poirier@umontreal.ca., Miron JP; Centre de Recherche du CHUM (CRCHUM), Université de Montréal, Montréal, Québec, Canada; Interventional Psychiatry Program (IPP), UC San Diego School of Medicine, San Diego, CA, USA., Garel N; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Québec, Canada., Samson-Daoust E; Centre de recherche de l'Institut universitaire en santé mentale (CR-IUSMM), Université de Montréal, Montréal, Québec, Canada., Rizkallah E; Département de psychiatrie et d'addictologie, Université de Montréal, Montréal, Québec, Canada., Desbeaumes Jodoin V; Unité de Neuromodulation Psychiatrique (UNP), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du CHUM (CRCHUM), Université de Montréal, Montréal, Québec, Canada; Département de psychiatrie et d'addictologie, Université de Montréal, Montréal, Québec, Canada., Juster RP; Département de psychiatrie et d'addictologie, Université de Montréal, Montréal, Québec, Canada; Centre de recherche de l'Institut universitaire en santé mentale (CR-IUSMM), Université de Montréal, Montréal, Québec, Canada., Lespérance P; Unité de Neuromodulation Psychiatrique (UNP), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du CHUM (CRCHUM), Université de Montréal, Montréal, Québec, Canada; Département de psychiatrie et d'addictologie, Université de Montréal, Montréal, Québec, Canada.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2024 Oct; Vol. 340, pp. 116122. Date of Electronic Publication: 2024 Aug 03.
DOI: 10.1016/j.psychres.2024.116122
Abstrakt: This cohort study investigated whether allostatic load (AL) is associated with treatment response to repetitive transcranial magnetic stimulation (rTMS) in treatment-resistant depression (TRD). Pre-treatment blood samples measured AL across multiple systems. Pre- and post-treatment mood changes were assessed using the Montgomery-Åsberg Depression Rating Scale (MADRS). Associations between AL and treatment outcomes were explored. Higher pre-treatment AL was significantly associated with poorer post-treatment response status but was not significantly associated with smaller reduction in MADRS score after 4 weeks of treatment. Identifying biomarker profiles informed by the AL model could enhance treatment decisions in TRD, reducing risks associated with prolonged, ineffective rTMS trials and emphasizing the need for reliable predictive biomarkers.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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