Mitochondrial-derived compartments remove surplus proteins from the outer mitochondrial membrane.
| Autor: | Wilson ZN; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Balasubramaniam SS; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Wong S; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Schuler MH; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Wopat MJ; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Hughes AL; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | The Journal of cell biology [J Cell Biol] 2024 Nov 04; Vol. 223 (11). Date of Electronic Publication: 2024 Aug 13. |
| DOI: | 10.1083/jcb.202307036 |
| Abstrakt: | The outer mitochondrial membrane (OMM) creates a boundary that imports most of the mitochondrial proteome while removing extraneous or damaged proteins. How the OMM senses aberrant proteins and remodels to maintain OMM integrity remains unresolved. Previously, we identified a mitochondrial remodeling mechanism called the mitochondrial-derived compartment (MDC) that removes a subset of the mitochondrial proteome. Here, we show that MDCs specifically sequester proteins localized only at the OMM, providing an explanation for how select mitochondrial proteins are incorporated into MDCs. Remarkably, selective sorting into MDCs also occurs within the OMM, as subunits of the translocase of the outer membrane (TOM) complex are excluded from MDCs unless assembly of the TOM complex is impaired. Considering that overloading the OMM with mitochondrial membrane proteins or mistargeted tail-anchored membrane proteins induces MDCs to form and sequester these proteins, we propose that one functional role of MDCs is to create an OMM-enriched trap that segregates and sequesters excess proteins from the mitochondrial surface. (© 2024 Wilson et al.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|